摘要
目的通过对不同年龄段自发性高血压大鼠(SHR)的脉搏波传导速度(PWV)的测定,以及同期SHR主动脉中膜横截面积(MCSA)结构分析,揭示SHR不同生长阶段血管生理变化。方法使用彩色超声多普勒和测定血管病理分析对4月龄、6月龄、8月龄、10月龄、12月龄的SHR进行PWV测定及MCSA分析。结果随年龄的增长, SHR的PWV开始升高。12月龄SHR的PWV显著高于8月龄、6月龄及4月龄组大鼠(P<0.05)。10月龄SHR的PWV显著高于6月龄组和4月龄组大鼠(P<0.05)。MCSA分析显示,随着年龄的增加,SHR主动脉MCSA也呈现逐步上升的趋势。结论随着年龄的增长,SHR动脉顺应性变差,血管弹性功能降低,动脉硬化程度增强。
Objective To reveal the physiological changes of blood vessels in different growth stages of spontaneous hypertensive rats(SHR)by measuring the pulse wave velocity(PWV)and analyzing the structure of aortic media cross-sectional area(MCSA)in the same period of SHR.Methods Color Doppler ultrasonography and vascular pathological analysis were used to determine PWV and MCSA of SHR at 4,6,8,10 and 12 month of age.Results The PWV of 12-month-old SHR was significantly higher than that of 8-month-old,6-month-old and 4-month-old SHR respectively(P<0.05).The PWV of 10-month-old SHR was significantly higher than that of 6-month-old and 4-month-old SHR respectively(P<0.05).Meanwhile,the MCSA analysis of SHR showed that the aortic MCSA of SHR increased gradually with age.Conclusion With the increase of age,the arterial compliance of SHR is worse,the vascular elasticity is decreased,and the degree of atherosclerosis is enhanced.
作者
郭菁
顾文勇
吴永杰
GUO Jing;GU Wenyong;WU Yongjie(Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Institute of Hypertension,Shanghai Key Laboratory of Hypertension,Shanghai 200025,China)
出处
《实验动物与比较医学》
CAS
2020年第2期141-143,共3页
Laboratory Animal and Comparative Medicine
