血栓弹力图对炎症性肠病患者高凝状态的监测价值研究

Value of thromboelastography in hypercoagulation monitoring in patients with inflammatory bowel disease

目的探讨血栓弹力图(TEG)对炎症性肠病(IBD)患者高凝状态的监测价值。方法纳入2019年1月至12月在同济大学附属第十人民医院住院的14例活动期溃疡性结肠炎(UC)患者、12例活动期克罗恩病(CD)患者以及21名同期健康体检者,比较3组的TEG指标、血小板、纤维蛋白原(Fib)水平,并分析TEG与血小板、Fib、C-反应蛋白(CRP)的相关性。结果与健康对照组相比,UC组与CD组的凝血综合指数(CI)、血凝块形成速率(Angle)、血栓最大幅度(MA)明显升高,血小板、Fib明显升高,凝血形成时间(K)明显降低,差异有统计学意义。CI、Angle、MA与血小板、Fib呈正相关,K与血小板、Fib呈负相关。CI、Angle、MA、K与CRP无相关性。结论TEG可监测IBD患者的高凝状态。

Objective This paper is intended to explore the value of thromboelastography(TEG)in monitoring hypercoagulability in patients with inflammatory bowel disease(IBD).Methods Fourteen patients with active ulcerative colitis(UC),twelve patients with active Crohn′s disease(CD),and 21 healthy people who underwent medical examinations in the same period of time from January to December 2019 in Tenth People′s Hospital of Tongji University were enrolled in the experiment.The TEG indexes(CI,R,K,Angle,MA,EPL,LY30),platelets,and fibrinogen(Fib)levels of the three groups were compared,and the correlation between TEG and platelets,Fib,and C-reactive protein(CRP)was analyzed.Results Compared with the healthy control group,the CI,Angle,MA,platelet,and Fib in the UC and CD group were significantly increased,but the K was significantly decreased,with statistically significant differences.The CI,Angle,and MA were positively correlated with platelet and Fib,but the K was negatively correlated with platelet and Fib.There is no correlation between CI,Angle,MA,K and CRP.Conclusion TEG can monitor the hypercoagulable state of IBD patients.