载化疗药磁性氧化铁纳米颗粒诊疗肿瘤的研究进展

Research progress in the diagnosis and treatment of tumors by magnetic iron oxide nanoparticles with chemotherapeutics

磁性纳米粒(nanoparticles,NPs)由于其独特的性质而受到广泛的关注.NPs可以与荧光染料、肿瘤靶向分子或化疗药物等相结合实现肿瘤靶向诊疗一体化.磁性氧化铁纳米颗粒(iron oxide nanoparticles,IONP)具有粒径小、生物安全性高、超顺磁性等优点.IONP除了具有影响T2加权成像(T2 weight imaging,T2WI)外,还具有药载和磁靶向等功能,是目前肿瘤诊疗的研究热点.笔者对IONP成像性能、肿瘤靶向性及载不同化疗药等方面的研究进行综述.

Magnetic oxygen nanoparticles(NPs)have attracted wide attention due to their unique properties.NPs can be combined with fluorescent probes,biological targeting molecules or anti-tumor drugs to achieve the multifunctionality of magnetic nanoparticles,so they have good application prospects in multimodal imaging,targeted diagnosis and treatment of cancer.Magnetic iron oxide nanoparticles(IONP)have the advantages of small particle size,high biological safety,and superparamagnetism.In addition to T2 weight imaging(T2WI)MR imaging,IONP also has drug loading and magnetic targeting functions.It is currently a hot research topic in cancer diagnosis and treatment.This article reviews the research on IONP imaging performance,tumor targeting,and the emphasis on carrying different types of chemotherapy drugs.