外周神经损伤后小鼠背根节神经ceRNA网络构建

Construction of ceRNA Network of Dorsal Root Ganglion Nerve in Mice after Peripheral Nerve Injury

目前,对外周神经损伤后神经元基因表达改变的研究主要集中于背根节和脊髓神经元中,特别是背根节神经元已成为这方面研究的主要切入点。背根节神经元是初级感觉神经元,研究其基因表达的意义主要在于了解痛觉机制。因此,主要就外周神经损伤后小鼠背根节神经内源竞争RNA(ceRNA)网络的构建进行探讨,这些异常表达的基因在背根神经节疼痛免疫等方面的产生发展提供了初步研究基础,为今后设计针对性强副作用低的药物和治疗手段提供了潜在的药物靶点。

At present,the research on gene expression changes of neurons after peripheral nerve injury mainly focuses on dorsal root ganglion and spinal cord neurons,especially dorsal root ganglion neurons have become the main entry point of this research.Dorsal root ganglion neurons are primary sensory neurons,so the significance of studying their gene expression lies in understanding the mechanism of pain.Therefore,the construction of endogenous competitive RNA(ceRNA)network in DRG of mice after peripheral nerve injury is mainly discussed.These abnormal genes provide a preliminary research basis for the generation and development of DRG pain immunity,and provide a potential drug target for the design of targeted drugs and treatment methods with strong side effects and low side effects in the future.