淋巴细胞与单核细胞比值对食管癌患者预后相关性的Meta分析

Prognostic Significance of Lymphocyte-to-monocyte Ratio in Esophageal Cancer:A Systematic Review and Meta-analysis

目的Meta分析方法研究淋巴细胞与单核细胞比值(LMR)与食管癌的预后相关性。方法计算机检索PubMed、Cochrane Library、Embase、万方、知网、维普等数据库,收集有关LMR与食管癌预后相关性的文献。进行文献筛选及质量评价、数据提取,使用Stata软件进行Meta分析。结果本Meta共纳入11篇文献,共3655例食管癌病例。低LMR的食管癌患者有较差的总生存(OS)(HR=1.32,95%CI为1.12~1.57,P=0.001),无病生存期(DFS)(HR=1.19,95%CI:1.09~1.31,P<0.001),以及肿瘤特异性生存(CSS)(HR=1.70,95%CI:1.36~2.13,P<0.001)。本研究不存在发表偏倚(P>0.05)。结论低LMR可能与食管癌患者的不良预后相关,可作为一种评估食管癌患者预后潜在的生物标志物。

Objective To explore the relationship between Lymphocyte-to-monocyte ratio(LMR)and prognosis in esophageal cancer.Methods The relevant studies were searched in databases of PubMed,Cochrane Library,Embase,Chinese CNKI,Wan Fang,VIP,and so on.Two researchers independently performed literature screening,quality evaluation,and data extraction,and Meta-analysis with Stata software.Results According to the inclusion and exclusion criteria,eleven articles with 3655 esophageal cancer patients were included in total.The results showed that patients with low LMR had a poor OS(HR=1.32,95%CI:1.12~1.57,P=0.001),DFS(HR=1.19,95%CI:1.09~1.31,P<0.001)and CSS(HR=1.70,95%CI:1.36~2.13,P<0.001).The Begg′s test biased evaluation showed no publication bias(P>0.05).Conclusion This meta-analysis suggests that low LMR is associated with poor prognosis and can be used as a potential biomarker to evaluate the prognosis of patients with esophageal cancer.