不同抗性水平家蝇对有机磷、拟除虫菊酯等药剂的交互抗性研究

Studies on the Cross-resistance to Organophosphorus and Pyrethroids in Housefly Strains Possessing Different Level Resistance to Phoxim and Deltamethrin

报道对辛硫磷和溴氰菊酯具有不同抗性水平的家蝇对有机磷、拟除虫菊酯及其他药剂的交互抗性情况和生化机制。处于高抗（R／S为625）和极高抗（R／S为547276）水平的抗溴氰菊酯家蝇、以及处于中抗（R／S为21．89）和高抗（R／S为310．72）水平的抗辛硫磷家蝇，对DDT及拟除虫菊酯类药剂均表现出明显的交互抗性；处于高抗和极高抗的抗溴氰菊酯家蝇以及处于中抗的抗干硫磷家蝇，对灭多威、abamectin及有机磷类药剂均不表现交互抗性；但处于高抗的抗辛硫磷家蝇则对有机磷类药剂表现出中等水平的交互抗性，对灭多威和abamectin无交互抗性。离休酶系分析结果表明，不同抗性水平家蝇的交互抗性情况不同，这与家蝇体内酯酶、多功能氧化酶、谷胱甘肽-S-转移酶和乙酸胆碱酯酶的酶活或特性存在差异有关。

Housefly (Musca domestica vicina Marquact) strains having high level (625-fold)and superhigh level (547276-fold) resistance to deltamethrin and housefly strains having moderate level (21- 89-fold) and high level (310. 72-fold) resistance to phoxim all showed strong cross-resistance to DDT and pyrethroids. But both strains of housefly resistant to deltamethrin and the strain that has moderate level resistance to phoxim showed no cross-resistance to organophosphorus. However,the strain that has high level resistance to phoxim showed moderate level cross-resistance to organophosphorus. Biochemical studies suggested that,the difference of enzyme activities or properties of esterase (carboxylesterase), mixedfunction oxidase, glutathione-S-transferase and acetylcholinesterase in houseflies were responsible for the different spectrums of cross-resistance of the four strains.