腔镜下甲状旁腺全切联合自体移植术治疗继发性甲状旁腺亢进的临床观察

Clinical Observation on Laparoscopic Total Parathyroidectomy Combined with Autograft in the Treatment of Secondary Hyperparathyroidism

目的探讨腔镜下甲状旁腺全切联合自体移植术治疗继发性甲状旁腺亢进的临床效果。方法 116例继发性甲状旁腺亢进患者均行腔镜下甲状旁腺全切联合自体移植术,测定手术前后的血清甲状旁腺激素水平与血清钙水平,记录临床症状改变、并发症、复发情况。结果术后,患者的血清甲状旁腺激素水平、血清钙水平均显著低于术前(P <0.05)。低钙血症发生率为25.86%。结论腔镜下甲状旁腺全切联合自体移植术治疗继发性甲状旁腺亢进,可有效缓解临床症状,降低血清甲状旁腺激素和钙水平。

Objective To explore the clinical effect of laparoscopic total parathyroidectomy combined with autograft in the treatment of secondary hyperparathyroidism.Methods 116 patients with secondary hyperparathyroidism received laparoscopic total parathyroidectomy combined with autograft.The levels of serum parathyroid hormone and serum calcium before and after surgery were measured,and the changes of clinical symptoms,complications and recurrence were recorded.Results After surgery,patients'serum parathyroid hormone level and serum calcium level were significantly lower than those before surgery(P<0.05).The incidence of hypocalcemia was 25.86%.Conclusions Laparoscopic total parathyroidectomy combined with autograft in the treatment of secondary hyperparathyroidism can effectively relieve clinical symptoms,and reduce the levels of serum parathyroid hormone and calcium.