右美托咪定镇静对重度子痫前期患者炎性反应的影响

Effect of Dexmedetomidine Sedation on Inflammatory Response in Patients with Severe Pre-Eclampsia

目的探讨右美托咪定镇静对重度子痫前期患者炎性反应的影响。方法选取重度子痫前期患者50例,随机分为对照组(咪达唑仑联合硫酸镁治疗,25例)和右美托咪定组(右美托咪定联合硫酸镁治疗,25例)。比较两组治疗前后的血清炎性因子、心率(HR)、平均动脉压(MAP),以及ICU住院时间。结果治疗24 h,两组的CRP、IL-6、TNF-α、HR、MAP水平均较治疗前显著降低,且右美托咪定组的各项指标均显著低于对照组(P<0.05)。右美托咪定组的ICU住院时间显著短于对照组(P<0.05)。结论给予重度子痫前期患者右美托咪定镇静,可减轻患者的炎性反应,提高临床疗效。

Objective To explore the effect of dexmedetomidine sedation on inflammatory response in patients with severe pre-eclampsia.%Methods 50 patients with severe pre-eclampsia were selected and randomly divided into two groups,with 25 cases in each group.The control group was treated with midazolam combined with magnesium sulfate,and the dexmedetomidine group was treated with dexmedetomidine combined with magnesium sulfate.The serum inflammatory factors,heart rate(HR),mean arterial pressure(MAP)before and after treatment,and the ICU hospitalization time were compared between the two groups.%Results After treatment for 24 h,the levels of CRP,IL-6,TNF-α,HR and MAP in both groups were significantly lower than those before treatment,and the indicators in the dexmedetomidine group were significantly lower than those in the control group(P<0.05).The ICU hospitalization time in the dexmedetomidine group was significantly shorter than that in the control group(P<0.05).%Conclusions Dexmedetomidine sedation applied in patients with severe pre-eclampsia can relieve patients’inflammatory response,and improve the clinical efficacy.