丙泊酚静脉麻醉与七氟烷吸入维持麻醉在老年良性前列腺增生患者中的比较分析

Comparative Analysis on Propofol for Intravenous Anesthesia and Sevoflurane Inhalation for Maintain Anesthesia in Elderly Patients with Benign Prostatic Hyperplasia

目的研究丙泊酚静脉麻醉与七氟烷吸入维持麻醉在老年良性前列腺增生(BPH)患者中的应用效果。方法选取260例全麻下行经尿道前列腺双极电切术的老年BPH患者,根据麻醉用药方案分为两组各130例。七氟烷组采用七氟烷吸入维持麻醉,丙泊酚组采用丙泊酚静脉麻醉。比较两组的麻醉恢复情况、生化指标以及认知功能(MMSE评分)。结果两组的恢复自主呼吸时间、定向力恢复时间、苏醒时间无显著差异(P>0.05)。术后24 h,丙泊酚组的血清NGF显著高于七氟烷组,血清NSE显著低于七氟烷组(P<0.05)。术后6 h、12 h,丙泊酚组的MMSE评分显著高于七氟烷组(P<0.05)。结论相对于七氟烷吸入维持麻醉,丙泊酚静脉麻醉对BPH患者血清NGF、NSE水平以及认知功能的影响更小。

Objective To study the application effects of propofol for intravenous anesthesia and sevoflurane inhalation for maintain anesthesia in elderly patients with benign prostatic hyperplasia(BPH).Methods 260 elderly BPH patients with transurethral bipolar resection of the prostate under general anesthesia were selected and equally divided into two groups according to the anesthetic regimen.Sevoflurane group received sevoflurane inhalation for maintain anesthesia,and propofol group was anesthetized by intravenous propofol.The recovery of anesthesia,biochemical indicators and cognitive function(MMSE score)were compared between two groups.Results No significant difference was found between two groups in the spontaneous breathing recovery time,orientation force recovery time and awakening time(P>0.05).At 24 h after surgery,the serum NGF of propofol group was significantly higher than that of sevoflurane group,and the serum NSE was significantly lower than that of sevoflurane group(P<0.05).The MMSE scores at 6 and 12 h after surgery of propofol group were significantly higher than those of sevoflurane group(P<0.05).Conclusions Compared with sevoflurane inhalation for maintenance anesthesia,propofol for intravenous anesthesia has less impact on the serum NGF and NSE levels and the cognitive function of BPH patients.