瑞巴派特联合传统用药治疗胃溃疡伴胃出血患者的效果及对炎症因子水平的影响

Effect of Ribapamide Combined with Traditional Medicine in the Treatment of Gastric Ulcer with Gastric Hemorrhage and Its Effect on Inflammatory Factor Levels

目的:研究瑞巴派特联合传统用药治疗胃溃疡伴胃出血患者的效果,观察对炎症因子和胃泌素(GAS)水平的影响。方法:选择2016年1月-2019年11月笔者所在医院收治的胃溃疡伴胃出血的患者50例,使用随机数字表法将患者分为传统组和联合组,各25例,传统组采用奥美拉唑和谷氨酰胺进行治疗,联合组在传统组的基础上采用瑞巴派特联合治疗。对比两组患者的临床疗效和炎症因子和GAS水平,以及不良反应情况。结果:联合组总有效率(96.00%)高于传统组(76.00%),差异有统计学意义(P<0.05)。治疗后,联合组白细胞介素-1、白细胞介素-6和GAS低于传统组,差异均有统计学意义(P<0.05)。联合组不良反应发生率(8.00%)低于对照组(28.00%),差异有统计学意义(P<0.05)。结论:瑞巴派特联合传统用药治疗胃溃疡伴胃出血患者的临床效果显著,能够改善患者的炎症因子和GAS水平。

Objective:To study the effect of Ribapamide combined with traditional medicine in the treatment of gastric ulcer with gastric hemorrhage and its effect on the levels of inflammatory factors and gastrin(GAS).Method:From January 2016 to November 2019,50 patients with gastric ulcer and gastric hemorrhage were selected.The patients were divided into the traditional group and the combined group with 25 cases in each.The traditional group was treated with Omeprazole and Glutamine,and the combined group was treated with Ribapamide on the basis of the traditional group.The clinical effects,inflammatory factors,GAS levels and adverse reactions of the two groups were compared.Result:The effective rate of the combined group(96.00%)was higher than that of the traditional group(76.00%),the difference was statistically significant(P<0.05).After treatment,the levels of IL-1,IL-6 and GAS in the combined group were lower than those in the traditional group,the differences were statistically significant(P<0.05).And the incidence of adverse reactions in the combined group(8.00%)was lower than that in the control group(28.00%),the difference was statistically significant(P<0.05).Conclusion:The clinical effect of Ribapamide combined with traditional medicine in the treatment of gastric ulcer with gastric hemorrhage is significant,which can improve the level of inflammatory factors and GAS in patients.