AE并癫痫的临床特征研究综述

Review of Clinical Characteristics of AE Complicated Epilepsy

自身免疫性脑炎(AE)主要是由自身免疫机制介导的脑炎类型,表现形式多样,其中最常见表现形式之一为癫痫发作。AE并癫痫发病机制复杂,考虑与AE相关抗体所致免疫反应等因素有关,若不及时治疗,可导致病情进展,甚至出现癫痫持续状态。单纯抗癫痫药物治疗AE并癫痫的效果有限,且目前临床就AE并癫痫患者院外抗癫痫药物选择、停药指征等仍无明确定论。文章现就近几年国内外针对AE并癫痫患者临床特征的研究进行综述,以期为相关实践、研究提供一定参考依据。

Autoimmune encephalitis(AE)is a type of encephalitis mediated mainly by autoimmune mechanisms.The pathogenesis of AE and epilepsy is complicated,which is related to factors such as the immune response caused by AE-related antibodies.If not treated in time,the disease may progress,and even the state of epilepsy may continue.The effect of single antiepileptic drugs on the treatment of AE complicated epilepsy is limited,and there is still no clear conclusion on the selection of antiepileptic drugs outside the hospital and the indication of drug withdrawal for patients with AE complicated epilepsy.This article reviews the domestic and foreign studies on the clinical characteristics of patients with AE complicated epilepsy in recent years,hoping to provide some references for relevant practice and research.