乌司他丁联合甲基强的松龙治疗川崎病患儿的疗效及炎症反应分析

Efficacy and inflammatory response analysis of ulinastatin combined with methylprednisolone in the treatment of children with kawasaki disease

目的探讨乌司他丁联合甲基强的松龙治疗川崎病的临床效果。方法选取我院收治的川崎病患儿87例,按治疗方案分两组,观察组44例、对照组43例。对照组予以常规治疗,观察组在对照组基础上予以乌司他丁联合甲基强的松龙治疗。比较两组疗效、症状缓解情况(发热消退时间、住院时间)、治疗前后血清C反应蛋白(CRP)、血沉(ESR)反应情况。结果两组疗效比较,观察组高于对照组(P<0.05);观察组发热消退时间、住院时间较对照组短(P<0.05);治疗后两组血清CRP水平、ESR均降低,且观察组低于对照组(P<0.05)。结论乌司他丁联合甲基强的松龙治疗川崎病疗效显著,能有效促进病情转归,缓解炎症反应。

Objective To explore the clinical effect of ulinastatin combined with methylprednisolone in the treatment of kawasaki disease. Methods 87 children with kawasaki were selected and divided into the experiment group(44 cases) and the control group(43 cases) according to the treatment plan. The control group received routine treatment, and the experiment group was treated with ulinastatin combined with methylprednisolone on the basis of the control group. The efficacy, symptom relief(fever regression time, hospitalization time), and inflammatory response [serum C-reactive protein(CRP), erythrocyte sedimentation rate(ESR)] before and after treatment were compared between the two groups. Results The total effective rate of the experiment group was higher than that of the control group(P<0.05). The fever regression time and hospitalization time of the experiment group were shorter than those of the control group(P<0.05). Serum CRP level and ESR level decreased in both groups after treatment, and those in the experiment group were lower than those in the control group(P<0.05). Conclusion Ulinastatin combined with methylprednisolone is effective in the treatment of kawasaki disease, which can effectively promote the outcome and alleviate the inflammatory response.