非小细胞肺癌调强放射治疗前后外周血淋巴细胞亚群变化的临床研究

Clinical study of peripheral blood lymphocyte subsets changes before and after IMRT for non-small cell lung cancer

目的分析非小细胞肺癌患者调强放疗(IMRT)前后外周血淋巴细胞亚群的变化,探讨该变化对患者免疫功能的影响。方法选择我院收治的非小细胞肺癌患者60例作为观察组,另选择同期健康查体者30例作为对照组,观察组接受6MV X线调强放射治疗,检测并比较观察组放疗前及放疗后1个月患者CD3+/CD4+、CD8+的变化,同时比较观察组放疗前后与对照组CD4+、CD8+水平。结果调强放射治疗前,观察组患者外周血CD3+细胞数、CD4+细胞数及CD4+/CD8+所测数据均明显低于对照组的健康人群,而CD8+细胞所占比值明显高于对照组健康人群(P<0.05);调强放射治疗后,观察组患者外周血CD3+细胞数、CD4+细胞数、CD8+细胞数所占比值及CD4+/CD8+比值与治疗前比较不存在统计学差异(P>0.05),观察组患者外周血CD3+细胞数、CD4+细胞数及CD4+/CD8+所测数据明显低于对照组健康成人群,与放疗前一样CD8+比值明显高于对照组健康人群(P<0.05)。结论非小细胞肺癌患者其免疫力低于正常人群,然而调强放射治疗对T淋巴细胞亚群水平影响不明显。

Objective To analyze the changes of peripheral blood lymphocyte subsets before and after intensity modulated radiotherapy(IMRT) for non-small cell lung cancer and discuss its influence on immunologic function. Methods A total of 60 patients with non-small cell lung cancer in our hospital were selected as the experiment group and at the same time 30 healthy adult were selected as the control group. Patients in experiment group received the treatment of 6 MV X-ray. The changes of CD3+/CD4+and CD8+in the experimental group before and after treatment were compared and the levels of CD4+and CD8+were compared between the two groups before and after treatment. Results Before treatment the amount of peripheral blood CD3+,CD4+and CD4+/CD8+in the experiment group was obviously lower than those of the control group,while the percentage of peripheral blood CD8+in the experiment group was obviously higher than that of the control group(P<0.05). After treatment the amount of peripheral blood CD3+,CD4+, CD8+and CD4+/CD8+in experiment group had no significant difference with those before treatment(P>0.05). After treatment the amount of peripheral blood CD3+,CD4+and CD4+/CD8+in the experiment group was obviously lower than those of the control group,while the percentage of peripheral blood CD8+in the experiment group was obviously higher than that of the control group(P<0.05) Conclusion The immunologic function of patients with non-small cell lung cancer is lower than that of healthy people,but IMRT has less influence on the T lymphocyte subsets.