祛风止痒方辅助治疗儿童慢性荨麻疹血虚风燥证40例临床观察

Clinical observation on 40 cases of chronic urticaria in children with blood deficiency and wind-dryness syndrome treated by Qufeng Zhiyang Fang(祛风止痒方) as adjuvant therapy

目的观察祛风止痒方辅助治疗儿童慢性荨麻疹血虚风燥证的有效性、安全性及对血清白三烯B4(LTB4)、白三烯C4(LTC4)的影响。方法选取2018年1月至2019年1月杭州市富阳区第一人民医院儿科收治的慢性荨麻疹血虚风燥证患儿80例,按照随机数字表法分为治疗组与对照组,各40例。对照组给予西药氯雷他定片口服,治疗组在对照组治疗方法的基础上加用祛风止痒方治疗,连续治疗1个月后,评价2组的临床疗效,血清LTB4、LTC4水平的变化情况及不良反应。结果对照组总有效率为65.0%(26/40),治疗组为92.5%(37/40),2组比较,差异有统计学意义(P<0.05)。治疗前,2组临床症状、体征积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组临床症状、体征积分较同组治疗前均明显下降,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前,2组血清LTB4、LTC4水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组血清LTB4、LTC4水平较同组治疗前明显下降,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。对照组出现口干3例,轻度嗜睡2例,不良反应总发生率为12.5%(5/40);治疗组出现口干2例,轻度嗜睡1例,不良反应总发生率为7.5%(3/40)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论祛风止痒方辅助治疗儿童慢性荨麻疹血虚风燥证,可有效缓解临床症状,抑制炎症反应,不良反应小,值得在临床推广应用。

Objective To observe the efficacy and safety of Qufeng Zhiyang Fang(祛风止痒方) in adjuvant treatment of chronic urticaria in children with blood deficiency and wind-dryness syndrome and its effect on serum leukotriene B4(LTB4) and leukotriene C4(LTC4).Methods From January 2018 to January 2019,80 children with chronic urticaria admitted into pediatrics department in Hangzhou Fuyang the First People’s Hospital were divided into treatment group and control group according to random number table method,with 40 cases in each.The control group was given Western medicine loratadine tablets orally,on this basis,the treatment group was added with Qufeng Zhiyang Fang.After consecutive treatment for 1 month, the clinical efficacy,serum levels changes of LTB4,LTC4 and adverse reactions of the 2 groups were compared.Results The total effective rate of the control group was 65.0%(26/40),that of the treatment group was 92.5%(37/40),and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,there was no significant difference in clinical symptom and sign scores between the 2 groups(P>0.05),and they were comparable.After treatment,the clinical symptom and sign scores of the 2 groups decreased significantly compared with the same group before treatment,and the difference was statistically significant(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).Before treatment,there was no significant difference in serum levels of LTB4 and LTC4 between the 2 groups(P>0.05),and they were comparable.After treatment,the serum levels of LTB4 and LTC4 in the 2 groups decreased significantly compared with the same group before treatment,and the difference was statistically significant(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).There were 3 cases of dry mouth and 2 cases of mild somnolence in the control group,and the total incidence of adverse reactions was 12.5%(5/40).There were 2 cases of dry mouth and 1 case of mild somnolence in the treatment group,and the total incidence of adverse reactions was 7.5%(3/40).There was no statistically significant difference in the total incidence of adverse reactions between the 2 groups(P>0.05).Conclusion It can effectively improve clinical symptoms and inhibit inflammatory reactions with less adverse reactions to use Qufeng Zhiyang Fang in adjuvant treatment of chronic urticaria in children with blood deficiency and wind-dryness syndrome, which deserves clinical promotion and application.