小儿柴桂退热颗粒辅助治疗小儿急性上呼吸道感染58例临床观察

Clinical observation on 58 cases of Xiao’er Chaigui Tuire Keli(小儿柴桂退热颗粒) in adjuvant treatment of children with acute upper respiratory infection

目的观察小儿柴桂退热颗粒辅助治疗小儿急性上呼吸道感染的临床疗效。方法选取2018年1月至2019年1月温岭市妇幼保健院儿科收治的急性上呼吸道感染患儿116例,按随机数字表法分为治疗组和对照组,各58例。对照组口服利巴韦林颗粒,治疗组在对照组治疗方法的基础上口服小儿柴桂退热颗粒,2组均治疗6 d后比较临床疗效、临床症状(发热、咳嗽、鼻塞、流涕、咽痛)消失时间和不良反应发生情况。结果治疗组临床症状消失时间均显著短于对照组,2组比较,差异均有统计学意义(P<0.05)。治疗组总有效率为91.38%(53/58),显著高于对照组的79.32%(46/58),2组比较,差异有统计学意义(P<0.05)。2组用药期间均未发生明显不良反应。结论小儿柴桂退热颗粒辅助治疗小儿急性上呼吸道感染临床疗效满意,可显著缩短临床症状消失时间,值得临床推广应用。

Objective To observe the clinical efficacy of Xiao’er Chaigui Tuire Keli(小儿柴桂退热颗粒) in adjuvant treatment of children with acute upper respiratory infection(AURI).Methods Totally 116 cases of AURI admitted into pediatrics department of Wenling Municipal Maternal and Child Health Hospital from January 2018 to January 2019 were divided into treatment group and control group according to random number table method,with 58 cases in each.The control group was given oral ribavirin granules,on this basis,the treatment group was given oral Xiao’er Chaigui Tuire Keli.After the 2 groups were both treated for 6 days,the clinical efficacy,the disappearance time of clinical symptoms(fever,cough,stuffy nose,runny nose and sore-throat) and incidence of adverse reactions were compared.Results The disappearance time of clinical symptoms in the treatment group was shorter than that in the control group,and the difference between the 2 groups was statistically significant(P<0.05).The total effective rate of the treatment group was 91.38%(53/58),which was significantly higher than 79.32%(46/58) of the control group, and the difference between the 2 groups was statistically significant(P<0.05).No significant adverse reactions occurred during medication period for the 2 groups.Conclusion It has satisfactory clinical efficacy and can significantly shorten the disappearance time of clinical symptoms to use Xiao’er Chaigui Tuire Keli in adjuvant treatment of children with AURI,which deserves clinical promotion and application.