129例FUO患者的临床研究及炎症指标对FUO诊断的分析

Clinical Study of 129 Patients with FUO and Analysis of Inflammation Indicators for Diagnosis of FUO

目的通过分析总结不明原因发热(FUO)患者的病种组成,评估现行的诊断指标(炎症反应标志物等)对于疾病的诊断价值,为今后的临床工作中对于诊断和治疗FUO提供参考。方法选取2018年12月至2019年9月蚌埠医学院第一附属医院收治的129例热程在2周以上的发热待查病例作为研究对象,按照随机数表法分为2组,即A组(改良定义组)和B组(经典定义组)。其中A组51例,B组78例。分析比较2组病例的基本情况、病种组成、确诊时间、患者的预后转归及临床特点、确诊时间、炎症标志物水平等指标。结果2组病例在一般情况、病种组成、确诊时间、未确诊病因转归上比较差异无统计学意义(P>0.05)。本次研究的FUO的确诊病例为110例,未确诊病例为19例。确诊病因主要包括:感染性疾病、非感染性疾病、肿瘤性疾病、其他混合疾病。炎症标志物[白细胞计数(WBC)、红细胞沉降率(ESR)、C反应蛋白(CRP)、降钙素原(PCT)]的测量值在不同疾病导致的FUO中存在一定差异。结论感染性疾病、肿瘤性疾病、非感染性炎症性疾病仍是FUO的主要病因。炎症标志物水平在不同疾病所致的FUO中显示出差异。

Objective By analyzing and summarizing the composition of patients with fever of unknown origin(FUO)and their disease types in our hospital,the current diagnostic indicators(markers of inflammatory response,etc.)are used to diagnose the disease,and provide a reference for future clinical diagnosis and treatment of FUO.Methods A total of 129 cases of fever with a fever duration of more than 2 weeks,which were admitted to the First Affiliated Hospital of Bengbu Medical College from December 2018 to September 2019,were selected as the study subjects and randomly divided into two groups,namely group A(modified definition group)and group B(classical definition group).There were 51 cases in group A and 78 cases in group B.The basic condition,disease composition,time of diagnosis,prognosis and prognosis,clinical characteristics,time of diagnosis,inflammation markers and other indicators of the two groups were analyzed and compare.Results There was no statistical difference in the general conditions,disease composition,diagnosis time,and undiagnosed prognosis of the two groups of patients.There were 110 confirmed cases of FUO and 19 undiagnosed cases in this study.The confirmed causes mainly include:infectious diseases,non-infectious diseases,neoplastic diseases,and other mixed diseases.The measured values of inflammation markers(WBC,ESR,CRP,PCT)have some differences in FUO caused by different diseases.Conclusion Infectious diseases,neoplastic diseases,and non-infectious inflammatory diseases are still the main causes of FUO.Inflammatory marker levels show differences in FUO caused by different diseases.