摘要
帕金森病(Parkinson’s disease,PD)是一种严重危害人体健康的神经退行性疾病。其典型病理变化为黑质纹状体内多巴胺能神经元坏死、缺失,以及表现出诸多运动障碍。该病病因尚未研究清晰,使用相关动物模型对研究该病具体作用机制与治疗手段具有重要意义。针对目前有关PD动物模型的研究现状,本文梳理了不同PD动物模型的特点,讨论了不同动物种类在PD模型中的不同特征,比较了动物模型与PD患者的临床差异,旨在为进一步深入开发PD动物模型提供参考。
Parkinson’s disease(PD)is a serious neurodegenerative disease.Typical pathological changes associated with PD are cellular necrosis and the loss of dopaminergic neurons in many areas of brain,as well as the appearance of multiple dyskinesias.Although the etiology of PD has not been clarified,the use of animal models plays a vital role in investigating the mechanisms of PD.In this article,we review the characteristics of different animal models of PD,discuss the characteristics of different animal species,and compare the clinical differences between animal models and PD patients to provide fundamental support for future PD research.
作者
杨东明
杨利峰
赵德明
周向梅
YANG Dongming;YANG Lifeng;ZHAO Deming;ZHOU Xiangmei(College of Veterinary Medicine,China Agricultural University,Beijing 100193,China)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2020年第3期397-404,共8页
Acta Laboratorium Animalis Scientia Sinica
基金
十三五国家重点研发计划(2017YFD0501600)。
