MicroRNAs对HIV-1复制的调节作用及应用展望

Micro RNAs regulate viral replication and latency in HIV-1 infection

微小核糖核酸(miRNAs)一种非编码小RNAs,在1型艾滋病病毒(HIV-1)感染的发展和转归中发挥重要作用。miRNAs通过直接作用于HIV RNA,或者通过间接调节细胞辅助因子和抗病毒因子抑制病毒复制,miRNAs也可以通过调节T细胞活化促进HIV感染。本文主要回顾在HIV-1感染者体内,异常表达的miRNAs通过多种途径促进病毒感染或者维持潜伏感染,及在感染过程中的生物调节作用。进一步研究miRNAs及其作用靶点在HIV-1感染者体内的作用可能为抗病毒治疗开启一个新的窗口。

MicroRNAs(miRNAs) are small noncoding RNAs and play an important role in development and return in HIV-1 infection. MiRNAs inhibit virus replication by targeting virus RNA directly or regulate viral accessory protein and cellar factors indirectly and it also promotes HIV infection by regulating T cell activation and proliferation. In this review, we focus on the biological functions to date of miRNAs in HIV-1 infection. The abnormal expression of miRNAs promotes viral infection or maintains latent infection according to various pathways. Further investigation into the relationship between miRNAs and the targets in HIV infectors will provide a new window for antiviral therapy of diseases.