脓毒症线粒体动态变化与功能障碍的研究进展

Advances of mitochondrial dynamics and dysfunction in sepsis

脓毒症是危重病患者的主要死因。线粒体功能障碍在脓毒症的发生、发展过程中发挥重要作用。文章介绍线粒体在细胞内的高度动态变化,包括线粒体的生物合成、自噬、融合分裂等均参与脓毒症多器官线粒体功能障碍(线粒体氧化、膜电位改变和线粒体呼吸功能)的过程,就线粒体动态变化和线粒体功能障碍在脓毒症器官(包括心、肺、肾、肝、脑等)损伤中的作用进行综述。从线粒体动态变化角度干预脓毒症的病理生理过程可能成为治疗脓毒症的新靶点。

Sepsis is the leading cause of death in critically ill patients.Mitochondrial dysfunction plays an important role in the occurrence and development of sepsis.This paper introduces the highly dynamic changes of mitochondria in cells,including mito‑chondrial biosynthesis,autophagy and fusion/fission,which are all involved in the process of mitochondrial dysfunction(mitochondrial oxidation,membrane potential changes and mitochondrial respiratory function)in septic multiple organs.This paper reviews the role of mitochondrial dynamics and mitochondrial dysfunction in septic organ injury(including heart,lung,kidney,liver,brain,etc.).Interven‑tion in the pathophysiological process of sepsis from the perspective of mitochondrial dynamics may become a new target for the treat‑ment of sepsis.