小檗碱及其衍生物抗寄生虫感染的研究进展

Advances in research of anti-parasitic infections by berberine and its derivatives

寄生虫病仍然是全球最大的健康问题,给贫困地区造成巨大的经济负担。目前用于治疗原虫病和蠕虫病的药物存在一定缺陷,亟待研发更为有效的治疗药物。小檗碱最早从黄连的根茎中提取获得,是一类重要的抗炎药物。小檗碱的衍生物通过修饰小檗碱的结构位点获得,除了具有抗菌和抗微生物活性以外,小檗碱及其衍生物还具有显著的抗寄生虫活性。本文概括了小檗碱及其衍生物抗原虫(利什曼原虫、锥虫、刚地弓形虫、恶性疟原虫和柔嫩艾美尔球虫)和蠕虫(曼氏血吸虫、日本血吸虫、细粒棘球绦虫和犬弓首蛔虫)感染的作用,以期为相关研究工作者提供参考。

Parasitic diseases still remain the world's greatest health problems and cause huge economic burden in poor areas.The drugs currently used to treat protozoiases and helminthiases have certain defects,and it is urgent to develop more effective therapeutic drugs for these diseases.Berberine is one kind of important anti-inflammatory agents originally derived from Coptis rhizoma.The derivatives of berberine are obtained by modifying the structural site of berberine.In addition to its anti-inflammatory and anti-microbial activities,berberine and its derivatives also have significant anti-parasitic activity.In this paper,we summarized recent progress in the use of berberine and its derivatives against the infections of protozoa(Leishmania spp.,Trypanosoma spp.,Toxoplasma gondii,Plasmodium falciparum,and Eimeria tenella)and helminths(Schistosoma mansoni,Schistosoma.japonicum,Echinococcus granulosus,and Toxocara canis),which may providea useful reference for researchers in this field.