RNA转运蛋白及其在肿瘤中的表达与功能

RNA transport proteins and their expression and function in tumors

恶性肿瘤严重影响人类健康和生存质量,其发生发展与多种RNA转运蛋白有关。正常情况下,RNA转运蛋白助力RNA分子的核浆穿梭及定位,有效地耦联细胞核与细胞质中的生命活动。肿瘤的发生及演进过程中,某些RNA转运蛋白的表达、定位异常或功能失调,可改变下游关键RNA分子细胞亚定位、表达水平、转运效率及细胞质mRNA衰变率,影响肿瘤的增殖、侵袭及转移。文章主要就RNA转运蛋白及其在肿瘤中的表达变化与调控作用展开综述。

Malignant tumors,whose occurrence and development are related to a variety of RNA transporter proteins,serious⁃ly affect human health and quality of life.Under normal circumstances,RNA transport proteins help RNA shuttle between nucleus and cytoplasm and their precise localization,effectively coupling the life activities in the nucleus and cytoplasm.During the process of tu⁃morigenesis and progression,the expression and localization of some RNA transporters are abnormal or dysfunctional,which can change the subcellular localization,expression level,transport efficiency of downstream key RNA molecules,and the decay rate of cytoplasmic mRNA,and affect the proliferation,invasion and metastasis of tumors.This paper mainly reviews RNA transport proteins and their ex⁃pression changes and regulation in tumors.