乌苯美司联合FOLFOX4方案治疗原发性胃癌近期疗效评价

Ubenmex Combined with FOLFOX4 Regimen for Primary Gastric Cancer

目的探讨乌苯美司联合FOLFOX4方案治疗原发性胃癌的近期临床疗效及对患者S期激酶相关蛋白2(Skp2)与细胞周期蛋白依赖性激酶抑制蛋白(P27kipl)水平的影响。方法选取医院2015年6月至2018年6月收治的原发性胃癌患者98例,按奇偶数法分为观察组和对照组,各49例。两组患者均予FOLFOX4方案治疗,观察组患者加服乌苯美司胶囊。两组均连续治疗3个周期。结果观察组总有效率为83.67%,显著高于对照组的65.31%(P<0.05);与治疗前比较,两组患者治疗后的CD3+和CD4+细胞阳性率、CD4+/CD8+及P27kipl水平均显著升高,CD8+细胞阳性率及Skp2水平均显著降低,观察组患者上述指标及改善程度均显著优于对照组(P<0.05);观察组与对照组不良反应发生率相当(26.53%比18.37%,χ2=0.938,P=0.333>0.05)。结论乌苯美司联合FOLFOX4方案治疗原发性胃癌,能提升患者的免疫功能,调节Skp2与P27kipl蛋白表达水平。

Objective To investigate the clinical efficacy of ubenmex combined with FOLFOX4 regimen for primary gastric cancer and its effect on the protein expression of S phase kinase-associated protein 2(Skp2)and protein kinase inhibitor P27kipl.Methods A total of 98 patients with primary gastric cancer admitted to the hospital from June 2015 to June 2018 were selected and divided into the observation group and control group according to odd or even numbers,49 cases in each group.The control group was treated with FOLFOX4 chemotherapy regimen,while the observation group was added with ubenmex on the basis of the control group.Both groups were treated for 3 continuous cycles.Results The total effective rate of the observation group was 83.67%,which was significantly higher than 65.31%of the control group(P<0.05).Compared with before treatment,the positive rate of CD3+,CD4+cells,the ratio of CD4+/CD8+,and the P27kipl protein levels were significantly increased,while the positive rate of CD8+cells and the Skp2 protein levels were significantly reduced in both groups;the improvements of the above indicators in the observation groups were significantly better than those of the control group(P<0.05).The incidences of adverse reactions in the observation group and the control group were equivalent(26.53%vs.18.37%,χ2=0.938,P=0.333>0.05).Conclusion Ubenmex combined with FOLFOX4 regimen is effective for primary gastric cancer.It can improve the immune function of patients,regulate the expression of Skp2 and P27kipl protein.