印度春季角结膜炎患儿血清维生素D的变化

Serum vitamin D in Indian children with vernal keratoconjunctivitis

目的:评估印度人群中春季角结膜炎(VKC)患者维生素D水平。方法:研究共纳入30名非特应性健康儿童和30名VKC儿童。比较两组间的血清维生素D水平和户外活动时间(P<0.05)。结果:VKC组血清维生素D平均水平(19.17±10.76 ng/mL)明显低于对照组(31.19±9.09 ng/mL)(P=0.0003)。43.33%的患者维生素D缺乏(10~20 ng/mL),而20%的VKC患者严重缺乏(<10 ng/mL)。维生素D的缺乏与VKC的严重程度相关(P<0.02)。VKC组户外时间为1.07±0.76h/每天,健康组户外时间为2.08±0.72h/每天(P<0.0001),与血清25(OH)D3水平显著相关(r=0.478,P<0.001)。结论:研究表明,VKC患儿的血清维生素D水平明显低于健康儿童,与户外活动时间有关。VKC的严重程度也与维生素D缺乏的严重程度相关,由此得出维生素D在维持眼表健康中发挥重要作用。

·AIM:To determine the vitamin D levels in vernal keratoconjunctivitis(VKC)patients in Indian population.·METHODS:A total of 30 non-atopic healthy children and 30 children having VKC were included in the study.The serum vitamin D levels and the time spent outside was compared between the two groups(P<0.05).·RESULTS:The mean serum vitamin D level in the VKC group was significantly lower(mean 19.17±10.76 ng/mL)compared to the control group(mean 31.19±9.09 ng/mL)(P=0.0003).The vitamin D levels were found to be deficient(10-20 ng/mL)in 43.33%,whereas severe deficiency(<10 ng/mL)was found in 20%of the VKC patients.The deficiency of vitamin D correlated with the level of severity of VKC(P<0.02).The time spent outside in the VKC group was 1.07±0.76h,whereas in the healthy subjects it was 2.08±0.72h(P<0.0001),and it showed a significant correlation with the serum 25(OH)D3 levels(r=0.478,P<0.001).·CONCLUSION:The study shows that children with VKC had a significantly lower serum vitamin D levels as compared to the healthy children which correlated with time spent outside.The severity of VKC also correlated with the severity of vitamin D deficiency which suggests that vitamin D plays an important role in maintaining ocular surface health.