基于文献的中医药治疗急性肺损伤、急性呼吸窘迫综合征用药规律研究

Study on the Medication Rules of Traditional Chinese Medicine in the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome Based on Literature

目的:急性肺损伤、急性呼吸窘迫综合征(ALI/ARDS)是新型冠状病毒肺炎(COVID-19)的致死性并发症,中医药在治疗ALI/ARDS中有其特殊的优势。基于文献挖掘技术总结急性肺损伤、急性呼吸窘迫综合征的中医诊疗进展。方法:选取中国知网数据库(CNKI)、维普全文数据库(VIP Database)、万方数据知识服务平台、PubMed医学文献检索服务系统、EMBASE数据库中口服或鼻饲中药治疗急性肺损伤、急性呼吸窘迫综合征的相关文献,录入文献中病因、证型、方剂、中药、效应指标等信息,规范用语后用Excel建立数据库,进行病因、证型、方剂、中药的频数统计分析,运用SPSS Clementine12.0软件进行证型-中药、中药间关联规则分析,获得的数据以Cytoscape进行网络化展示。结果:共纳入中文文献147篇,英文文献1篇。频数最多的5种病因分别是创伤、严重肺部感染、脓毒症、急性重症胰腺炎、腹腔感染。证型以肠热腑实证、痰热壅肺证、热毒壅滞证、血瘀证、阳明腑实证占比最多。治疗上以宣白承气汤、大承气汤、凉膈散为主,高频中药分别有大黄、厚朴、枳实、栀子、芒硝、甘草、黄芩、杏仁等,且不同证型用药规律不同。结论:根据数据挖掘结果,系统地分析出目前中医药治疗急性肺损伤、急性呼吸窘迫综合征的诊疗规律,为临床及科研提供参考依据。

Objective:Acute Lung Injury or Acute Respiratory Distress Syndrome(ALI/ARDS)are the fatal complications of coronavirus disease(COVID-19)in 2019.Traditional Chinese medicine(TCM)has its special advantages in the treatment of ALI/ARDS.The progress of diagnosis and treatment of TCM for acute lung injury and acute respiratory distress syndrome based on literature mining technology was summarized.Methods:Relevant literature on oral or nasal feeding TCM for acute lung injury and acute respiratory distress syndrome in the Chinese and English databases were collected,and the etiology,syndrome type,prescription,TCM,effect indicators and other information in the literature were entered to establish the database after standardizing the language using Excel.The frequency statistical analysis of the etiology,syndrome type,prescription,and TCM was carried out and SPSS Clementine12.0 software was used to analyze the association rules between syndrome type and TCM,and TCM.The data obtained was displayed on the network with Cytoscape.Results:A total of 147 Chinese documents and 1 English document were included.The 5 most frequent causes were trauma,severe pneumonia,sepsis,severe acute pancreatitis,and abdominal infection.The syndrome types were mostly the syndrome of intestinal fever and fu-viscera excess,phlegm-heat obstructing lung,syndrome of heat and toxin congestion and stagnation,syndrome of blood stasis,and syndrome of excess of Yangming fu-viscera excess.The main treatments were Xuanbai Chengqi Decoction,Dachengqi Decoction,and Liangge Powder.The high-frequency TCM were Radix et Rhizoma Rhei,Cortex Magnoliae Officinalis,Fructus Aurantii Immaturus,Fructus Gardeniae,Natrii Sulfas,Glycyrrhizae Radix et Rhizoma,Radix Scutellariae,Semen Armeniacsa Amarum,and different medication rules were for different syndrome.Conclusion:According to the results of the data mining,this paper systematically analyzes the diagnosis and treatment rules of TCM in the treatment of acute lung injury and acute respiratory distress syndrome,and provides reference for clinical and scientific research.