药物涂层球囊在急性ST段抬高型心肌梗死患者的即刻效果及近期疗效研究

Immediate and short-term effects of drug-coated balloon on patients with acute ST segment elevation myocardial infarction

目的评价药物涂层球囊(DCB)治疗急性ST段抬高型心肌梗死(STEMI)患者的即刻效果及近期疗效。方法符合入组条件的STEMI患者28例,收集患者DCB治疗后主要心血管事件及血管内超声等数据,分析患者术后即刻效果及近期预后。结果28例STEMI患者DCB治疗后冠脉夹层的发生率为14.29%(4/28),术后即刻治疗效果靶病变血管直径较术前明显增大[(2.42±0.36)mm vs(0.78±0.31)mm,P<0.001]。所有患者随访12个月后,4例(14.29%)夹层完全愈合,1例(3.57%)发生再狭窄,靶病变血管直径较术后即刻治疗效果无明显差异[(2.39±0.44)mm vs(2.42±0.36)mm,P=0.322],所有患者无死亡、心肌梗死或靶病变血运重建发生。结论STEMI患者行DCB治疗,临床观察显示术后即刻效果及近期疗效确切。

Objective To evaluate the immediate and short-term effects of drug coated balloon(DCB)on patients with acute ST segment elevation myocardial infarction.Methods Totally 28 patients with acute ST segment elevation myocardial infarction were enrolled in the study.The data of the immediate effect and shortterm efficacy were statistically analyzed in terms of major cardiovascular events and intravascular ultrasound during their follow-up.Results All 28 patients completed the follow-up,and DCB was implanted after the pretreatment.After DCB dilation,the coronary dissection was 14.29%(4/28).The diameter of the target vessel after the operation was significantly bigger after the operation[(2.42±0.36)mm vs(0.78±0.31)mm,P<0.001].After the 12 month follow-up,there was no acute ischemic event,4(14.29%)dissection healed completely,and 1(3.57%)restenosis.There was no significant difference in the diameter of the target vessel between the follow-up and the PCI[(2.39±0.44)mm vs(2.42±0.36)mm,P=0.322].During the follow-up after the DCB treatment,no death,myocardial infarction or target lesion revascularization occurred.Conclusion The immediate and short-term effects of DCB on STEMI are safe and effective.