蛋白聚糖4在骨关节炎中的作用研究进展

Research progress on role of proteoglycan 4 in osteoarthritis

蛋白聚糖4(proteoglycan 4, PRG4)是滑膜关节分泌的一种表面活性粘液糖蛋白,在维持关节软骨完整性中起着重要作用。在关节损伤、炎性关节疾病或蛋白聚糖4先天缺陷的患者中,由于其蛋白聚糖4不足,无法起到保护关节软骨的作用。研究表明,PRG4正作为一种新的生物治疗蛋白,用于骨关节炎的治疗研究,并在防止软骨表面损伤和保护软骨细胞方面发挥了重要作用。本文就蛋白聚糖4的结构和功能,以及其在骨关节炎治疗中的作用做一综述,为骨关节炎的治疗提供新思路。

Proteoglycan 4(Prg4)is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity.As arthropathy occurring due to trauma,inflammatory arthritis or genetically mediated proteoglycan 4 deficiencies,Prg4 is insufficient to prevent damage to articular cartilage.Recent studies indicate that Prg4 plays a role in preventing damage to the superficial zone and preservation of chondrocytes,and is being used as a new biological therapeutic protein in the treatment of osteoarthritis.This article reviews the structure and function of proteoglycan 4 and its role in the treatment of osteoarthritis.