摘要
目的:探讨验证地黄养阴颗粒的主要药效学,为临床用药服务。方法:取昆明小鼠60只,分为空白组、大剂量组、中剂量组、小剂量组和阳性组5组,每组12只小鼠。给药30 d后,①称取标记区域毛发重量;②使用图像分析系统测定微循环相关指标;③进行碳粒廓清实验,测定吞噬指数κ。比较各给药组指标和空白组间差异。结果:与空白组比较,10.0 g/kg、5.0 g/kg 2个剂量组可促进小鼠毛发生长,增加小鼠毛细血管开放量,提高小鼠毛细血管血流速度,扩大小鼠毛细血管输入、输出口径,明显增强了小鼠网状内皮系统的吞噬功能。结论:地黄养阴颗粒具有活血生发作用,初步证明对毛发松动或呈稀疏状脱落,毛发干燥或油腻等有效。
Objective:To study the main pharmacodynamics of Dihuang Yangyin Granules,and to serve clinical medicine.Method:Sixty KM mice were divided into 5 groups:control group,high-dose group,medium-dose group,low-dose group and positive group,with 12 mice in each group.①Weigh the hair in the marked area;②Use the image analysis system to determine the microcirculation-related indicators;③Perform the carbon particle clearance test to determine the phagocytosis indexκ.The differences between the indicators of each administration group and the control group were compared.Results:Compared with the control group,the dose groups of 10.0g/kg and 5.0g/kg can promote mouse hair growth,increase mouse capillary opening,promote mouse capillary blood flow velocity,increase mouse capillary input and output caliber,and significantly enhance the phagocytic function of the mouse reticuloendothelial system.Conclusion:Dihuang Yangyin granules have the effect of promoting blood circulation and hair growth,and have been shown to be effective in loosening or thinning hair,and drying or greasy hair.
作者
王莉
乔园
穆庆丽
郭冬
WANG Li;QIAO Yuan;MU Qingli(Xi’an XD Group Hospital ,Xi’an 719000)
出处
《陕西中医》
2020年第7期990-993,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
陕西省科技创新能力支撑项目(2019PT-27)。
关键词
斑秃
地黄养阴颗粒
KM小鼠
耳廓微循环
药效学
吞噬指数κ
毛细血管
Alopecia areata
Dihuang Yangyin Granules
KM mice
Auricle microcirculation
Pharmacodynamics
Phagocytosis indexκ
Capillary blood