妇科内分泌疾病与复发性流产的相关性

Study on the Correlation between Gynecological Endocrine Diseases and Recurrent Abortion

目的探讨妇科内分泌疾病与复发性流产的相关性。方法选取2016年2月至2019年2月钦州市第二人民医院就诊的反复自然流产患者62例,作为研究对象(A组),患者年龄23~40岁,平均(27.3±1.1)岁,自然流产3~7次,平均(3.13±1.34)次,月经周期28~32 d,平均(29.13±1.82) d。对照对象选取同期来我院接受体检健康,且妊娠正常的妇女62例,作为对照(B组)患者年龄22~41岁,平均(27.2±1.4)岁,月经周期28~32 d,平均(29.13±1.82) d。通过女性内分泌六项指标检查并统计其内分泌异常发生率比较;再选取同期来钦州市第二人民医院有健康分娩史的62例妇女为对照(C组),患者年龄在23~41岁,平均(27.8±1.5)岁,月经周期为28~32 d,平均月经周期为(29.12±1.62) d,进行Th1/Th2指标水平检测与比较;所有入选患者均接受内分泌水平检查,患者一般资料比较,差异无统计学意义(P>0.05)。结果 A、B两组妇女内分沁异常发生率比较来看,A组FSH (9.84%)、LH(4.92%)、E2 (3.28%)、P(3.28%)、T(9.84%)、PRL(13.11%)、异常发生率(44.26%)显著高于B组FSH(3.28%)、LH (0%)、E2(0%)、P(0%) T(0%)、PRL(0%)、异常发生率(3.28%);A\C两组Th1/Th2指标呈现异常的状态,组间比较存在显著差异,差异有统计学意义(P <0.05)。结论复发性流产的妇女六项内分泌指标均存在异常,且占比较高的集中在FSH、T、PRL,Th1/Th2指标呈现异常的状态,组间比较存在显著差异通过研究数据表明,妇科内分泌疾病与复发性流产可能存在相关性。

Objective To explore the correlation between gynecological endocrine diseases and recurrent abortion.Methods Sixty-two patients with recurrent spontaneous abortion who were treated in our hospital from February 2016 to February 2019 were selected as the research subjects(group A).The patients were 23-40 years old,with an average age of(27.3±1.1)years.The abortion ranged from 3 to 7 times,with an average of(3.13±1.34)times.The menstrual cycles were 28-32d.The average menstrual cycle was(29.13±1.82)d.Another 62 women who were healthy and received health check-ups in our hospital during the same period and had normal pregnancy were selected as the first control group.As the first control group(group B),the patients were 22-41 years old,with an average ageof(27.2±1.4)years.The menstrual cycles were 28-32 days.The average menstrual cycle was(29.13±1.82)days.Six female endocrine indicators were examined and compared for the incidence of endocrine abnormalities.The third group of 62 women with a history of healthy childbirth who came to our hospital during the same period were selected as the second control group(group C).The patients were 23-41 years old,with an average age of(27.8±1.5)years old.Their menstrual cycles were 28-32d,with an average menstrual cycle of(29.12±1.62)d,and their Th1/Th2 indicator levels were tested and compared.All selected patients were examined for endocrine levels,and the general information of the patients was compared and found without significant difference(P>0.05).Results For the incidence of internal division abnormalities in the two groups of A\B women,the FSH(9.84%),LH(4.92%),E2(3.28%),P(3.28%),T(9.84%),PRL(13.11%),abnormal incidence(44.26%)in group A were significantly higher than those in group B-FSH(3.28%),LH(0%),E2(0%),P(0%),T(0%),PRL(0%),and the incidence of abnormalities(3.28%).Th1/Th2 indicators in the A\C group showed an abnormal state,and there was a significant difference between the groups(P<0.05).Conclusion The six endocrine indicators are all abnormal in women with recurrent miscarriages,and abnormality was relatively more often concentrated in FSH,T,PRL,and Th1/Th2 indicators.There are significant differences between groups.Research data shows there may be a correlation between gynecological endocrine diseases and recurrent miscarriage.