细菌性阴道病患者人乳头瘤病毒基因检测及感染分析

Human papilloma virus gene detection and infection analysis in patients with bacterial vaginosis

目的研究人乳头瘤病毒(human papillomavirus,HPV)在细菌性阴道病患者中的基因分布情况并与健康体检人群进行对比。方法收集2018年在成都市妇女儿童中心医院就诊的患者样本,采用基因芯片技术对3313例细菌性阴道病患者和2101例健康体检人员进行宫颈HPV感染的基因检测。结果3313例细菌性阴道病患者HPV总感染率为28.1%,明显高于健康体检人员(17.94%)。其中以一重感染为主,感染阳性率为20.56%,健康体检人员一重感染率为14.23%,差异有统计学意义(P<0.05)。细菌性阴道病患者HPV检出率最高的3种高危基因型为HPV 52、HPV 16和HPV 51,健康体检者检出率最高的3种高危基因型为HPV 52、HPV 58和HPV 16。细菌性阴道病和健康体检人群均以单一高危感染为主,分别为550例(16.6%)和236例(11.23%),高于其它类型感染。结论细菌性阴道病患者HPV感染率明显高于健康体检人群,应高度重视并积极预防宫颈癌的发生。

Objective To investigate the gene distribution of human papillomavirus(HPV)in patients with bacterial vaginitis and compare it with the healthy population.Methods Genotypes of cervical HPV infection in 3313 patients with bacterial vaginitis and 2101 health check-up stuff were detected by gene chip technology and the samples were collected from patients in Chengdu Women and Children's Center Hospital in 2018.Results The total infection rate of HPV in 3313 patients with bacterial vaginitis was 28.1%,it was significantly higher than that of health check-up stuff(17.94%).Among them,mianly were single infection,the positive rate of infection was 20.56%,but the health check-up was 14.23%,the difference was statistically significant(P<0.05).HPV 52,HPV 16 and HPV 51 were the three genotypes with the highest detection rate in patients with bacterial vaginitis.HPV 52,HPV 58 and HPV 16 were the three genotypes with the highest detection rate in health check-up stuff.550 cases of bacterial vaginitis and 236 cases of heath check-up stuff were mainly single high-risk infection,the positive infection rate were 16.6%and 11.23%,higher than other types.Conclusion The infection rate of HPV in patients with bacterial vaginosis is obviously higher than that in healthy people.Therefore,great attention should be paid to it and active prevention should be taken.