西地那非对新生儿肺动脉高压患儿血浆细胞因子的影响及疗效研究

Effect of Sildenafil on plasma cytokines for pulmonary arterial hypertension newborns

目的探讨西地那非对新生儿肺动脉高压患儿血浆细胞因子的影响。方法选择2013年1月~2018年5月在我院治疗的肺动脉高压患儿84例,按照随机数字表法分为对照组与观察组各42例。对照组给予常规治疗,观察组在常规治疗上加用西地那非治疗,观察比较两组患儿的疗效以及治疗前后血浆细胞因子BNP、NT-proBNP水平及Ca^2+水平变化。结果观察组的总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后的BNP、NT-proBNP、Ca^2+水平均较治疗前明显改善,而观察组各指标水平改善明显优于对照组,差异均有统计学意义(P<0.05)。结论西地那非治疗新生儿肺动脉高压的效果显著,能有效改善患儿血浆细胞因子指标,安全性较好,值得推广。

Objective To discuss the influence of Sildenafil on plasma cytokines for pulmonary arterial hypertension newborns.Methods 84 newborns with pulmonary arterial hypertension(2013.01-2018.05)in our hospital were chosen and randomly assigned to two groups,42 cases in each group.The control group took the routine therapy;on the basis of the former,the test group took Sildenafil.The curative effect and plasma cytokine levels were compared.Results The total effective rate in the test group was higher than control group;after treatment,BNP(brain natriuretic peptide)and NT-proBNP(N-terminal pro-brain natriuretic peptide)levels in the test group were lower than control group;Ca^2+levels were higher than control group(P<0.05).Conclusion Sildenafil has obvious effects in pulmonary arterial hypertension newborns,which can efficiently improve the plasma cytokines and treatment safety.