FTO基因rs8050136多态性与多囊卵巢综合征相关性的Meta分析

The association between FTO gene rs8050136 polymorphism and polycystic ovary syndrome:A Meta-analysis

目的探讨肥胖相关基因(FTO)rs8050136多态位点与多囊卵巢综合征(PCOS)发病的相关性。方法检索Pubmed/MEDLINE、Embase、Web of Science、中国知网(CNKI)、万方数据库、维普中文期刊及中国生物医学文献数据库(CBM),检索时间范围为建库到2019年11月11日。按纳入、排除标准选择FTO基因rs8050136 A/C多态性与PCOS关系的病例对照研究。应用Rev-Man 5.2及STATA 11.2软件进行Meta分析。结果纳入5篇病例对照研究共2750例患者,其中PCOS组1238例,对照组1512例。Meta分析结果显示,未发现携带A等位基因者发生PCOS的危险性高于携带C等位基因者(OR=1.19,95%CI:0.98~1.43,P=0.08)。携带AA基因型的人群发生PCOS的风险是携带CC基因型人群的1.64倍(95%CI:1.02~2.63,P=0.04),未发现携带AC基因型的人群发生PCOS的风险较CC基因型人群增高(OR=1.20,95%CI:0.85~1.69,P=0.30)。结论FTO基因rs8050136多态性与PCOS发病相关。

Objective To explore the association between the polymorphisms of fat mass and obesity associated gene(FTO)rs8050136 and the risk of polycystic ovary syndrome(PCOS).Methods Pubmed/MEDLINE,Embase,Web of Science,CNKI,Wanfang database,VIP Chinese Journal and CBM were searched.The searching time was from the establishment to November 11,2019.According to the inclusion and exclusion criteria,case-control studies on the relationship between the FTO gene rs8050136 A/C polymorphism and PCOS were selected.The Rev-Man 5.2 and STATA 11.2 software were used for meta-analysis.Results Five case-control studies were included with a total of 2750 patients,including 1238 PCOS patients and 1512 controls.Meta-analysis showed that the risk of PCOS in people with A allele was not higher than that in people with C allele(OR=1.19,95%CI:0.98-1.43,P=0.08).The risk of PCOS in people with AA genotype was 1.64 times higher than that in people with CC genotype(95%CI:1.02-2.63,P=0.04)and the risk of PCOS in people with AC genotype was not higher than that in people with CC genotype(OR=1.20,95%CI:0.85-1.69,P=0.30).Conclusion rs8050136 polymorphism of FTO gene is associated with PCOS.