脑梗死1号方联合常规治疗对急性脑梗死患者的临床疗效

Clinical effects of No.1 Cerebral Infarction Decoction combined with routine treatment on patients with acute cerebral infarction

目的探讨脑梗死1号方联合常规治疗对急性脑梗死患者的临床疗效。方法 100例患者随机分为对照组和观察组,每组50例,对照组给予常规治疗(阿司匹林、丁基苯酞、依达拉奉、阿托伐他汀),观察组在对照组基础上加用脑梗死1号方,疗程14 d。检测中医证候疗效、NIHSS评分、神经功能指标(NSE、NGF、BDNF)、内皮功能指标(NO、ET-1、vWF、VEGF)变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组NIHSS评分及NSE、ET-1、vWF水平降低(P<0.05),NGF、BDNF、NO、VEGF水平升高(P<0.05),以观察组更明显(P<0.05)。结论脑梗死1号方联合常规治疗可提高急性脑梗死患者短期疗效,减轻神经功能损伤,其机制可能为改善血管内皮功能。

AIM To explore the clinical effects of No.1 Cerebral Infarction Decoction combined with routine treatment on patients with acute cerebral infarction.METHODS One hundred patients were randomly assigned into control group(50 cases) for 14-day intervention of routine treatment(aspirin, butylphthalide, edaravone, atorvastatin), and observation group(50 cases) for 14-day intervention of both No.1 Cerebral Infarction Decoction and routine treatment. The changes in TCM syndrome efficacy, NIHSS score, neurological function indices(NSE, NGF, BDNF) and endothelial function indices(NO, ET-1, vWF, VEGF), were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05). After the treatment, the two groups displayed decreased NIHSS score, NSE, ET-1 and vWF levels(P<0.05), and increased NGF, BDNF, NO and VEGF levels(P<0.05), especially for the observation group(P<0.05).CONCLUSION For the patients with acute cerebral infarction, No.1 Cerebral Infarction Decoction combined with routine treatment can enhance short-term efficacy and relieve neurological function impairment, whose mechanism may contribute to the improvement of vascular endothelial functions.