多模态磁共振成像联合血清胰高血糖素样肽1检测诊断阿尔茨海默症的价值观察

Value of Multimodal Magnetic Resonance Imaging Combined with Serum Glucagonlike Peptide 1 in the Diagnosis of Alzheimer's Disease

目的研究多模态磁共振联合血清胰岛高血糖素样肽1(GLP-1)检测诊断阿尔茨海默症(AD)的价值。方法将航天中心医院2018年06月~2019年06月间收治的30例AD患者纳为研究对象,并将30例认知功能正常的同龄老年患者纳为对照组,比较两组多模态MRI成像特点及血清GLP-1水平,分析MRI多模态成像联合血清GLP-1在诊断AD中的作用。结果多模态MRI提示,较对照组比,AD组患者存在广泛的灰质萎缩,双侧大脑半球大致对称的白质纤维束完整性受损,表现为FA值降低,MD值、RD值增加,穹隆体部及穹隆柱FA值下降,左侧内囊前后肢,左侧丘脑前辐射及双侧上额枕束的MD值或λ1值或RD值增加等;且AD组空腹状态下血清GLP-1水平显著高于对照组,服糖后1h、1.5h及2h后AD组血清GLP-1水平显著低于同时间段对照组水平(P<0.05)。结论多模型MRI能通过多参数有效提示AD患者脑组织形态及功能异常,此外,AD患者服糖前后血清GLP-1水平与健康者间存在显著差异,该改变在提示患者病情具有一定参考价值。

Objective To study the value of multimodal magnetic resonance imaging(MRI)combined with serum glucagon-like peptide 1(GLP-1)in the diagnosis of Alzheimer's disease(AD).Methods A total of 30 patients with AD admitted to the hospital of space center from June 2016 to June 2019 were selected as the study object,and 30 elderly patients of the same age with normal cognitive function were selected as the control group.The characteristics of multi-mode MRI and serum glp-1 level of the two groups were compared,and the role of MRI multi-mode imaging combined with serum glp-1 in the diagnosis of AD was analyzed.Results Multimodal MRI suggested that compared with control group,there was extensive gray matter atrophy and impaired integrity of roughly symmetric white fiber bundles in bilateral cerebral hemispheres in AD group,and the FA value was decreased while MD value and RD value were increased,and the FA values of corpora fornicis and fornicolumn were decreased,and the MD values orλ1 values or RD values of anterior and posterior limbs of left internal capsules,left thalamus radiation and bilateral upper frontal occipital bundles were increased.The fasting serum GLP-1 level in AD group was significantly higher than that in control group,and the serum GLP-1 level was significantly lower than that in control group at 1h,1.5h and 2h after taking glucose(P<0.05).Conclusion Multi-model MRI can effectively indicate brain tissue morphology and functional abnormalities in patients with AD through multi-parameters.In addition,serum glp-1 level of patients with AD before and after sugar administration is significantly different from that of healthy patients,which has certain reference value in indicating patients'condition.