质子泵抑制剂对慢性阻塞性肺病合并胃食管反流病患者的疗效分析

Effect of proton pump inhibitors on patients with chronic obstructive pulmonary disease and gastroesophageal reflux disease

目的分析质子泵抑制剂对慢性阻塞性肺病合并胃食管反流病(GERD)患者的疗效。方法选取2018年1月至2019年1月在新疆维吾尔自治区人民医院呼吸与危重症医学中心住院治疗的83例慢阻肺合并GERD患者作为研究对象。采用数字表法随机分为观察组和对照组。其中,观察组42例,给予抗炎解痉平喘化痰治加艾司奥美拉唑抑酸治疗;对照组41例,单纯给予抗炎性解塞性痉平喘化痰治疗。分别记录两组患者治疗前和治疗后6个月体质量指数(BMI)、GerdQ量表评分、慢阻肺病评估测试(CAT)问卷评分、用力肺活量(FVC)、1 s用力呼气容量(FEV1)、FEV1与FVC的百分比等肺功能指标。计量资料以均数±标准差(±s)表示,计数资料以构成比表示。治疗前后及组间的比较采用配对t检验或χ2检验。结果治疗前两组患者的性别(男/女)、年龄、BMI、病程、吸烟、饮酒、GerdQ评分、CAT评分等一般资料之间无明显差异(统计量:观察组n=42;对照组n=41;统计值t=分别为0.097,0.309,0.084,0.100,0.736,0.436,0.855,0.303;P>0.05)。与对照组相比,观察组治疗后FVC、EFV1、EFV1/FVC水平均显著升高,CAT评分、GerdQ评分水平均显著降低,差异均有统计学意义(统计量:观察组n=42;对照组n=41;统计值t=分别为12.957,14.573,5.446,-17.219,-5.156;P<0.05)。结论对慢阻肺合并GERD患者运用质子泵抑制剂治疗可更有效改善患者肺功能,缓解GERD症状,对病情控制效果更为显著。

Objective Analysis of clinical efficacy of proton pump inhibitors in patients with chronic obstructive pulmonary disease and GERD.Methods A total of 83 patients with COPD and GERD whom diagnosed and treated in our hospital from January 2018 to January 2019 were selected as study objects.Those patients were randomly divided into control group(41 cases)and observation group(42 cases).The control group given routine therapy that includes anti-inflammatory,anti-spasmodic and asthma-reducing phlegm drugs;Mean while,the observation group was given esmeprazole on the basis of control group.Two groups were treated for two weeks of period.Then,the GerdQ syptom score,COPD assessment test(CAT)score,and lung function such as FVC(L),EFV1(L),EFV1/FVC(%)of two groups pre and post treatment were analyzed.Results There were no significant differences between the two groups of general information such as gender(male/female),age,BMI,course of disease,smoking,drinking,GerdQ score,and CAT score(t=0.097,0.309,0.084,0.100,0.736,0.436,0.855,0.303;P>0.05);As compare to post-treatment in control group,the observation group showed greater improvement in the levels of FVC(L),EFV1(L),and EFV1/FVC(%),witch statistical significances(t=12.957,14.573,5.446,-17.219,-5.156;P<0.05);At the same time,levels of CAT score and GerdQ score were also significantly reduced in observation group(P<0.05).Conclusion The clinical efficacy of proton pump inhibitors may most effective in the ameliorating of GERD syptomes and lung function of COPD patients with GERD.