纯氧及LED阵列光动力复合治疗设备的研制

Development of a device for photodynamic therapy combining pure oxygen with LED array

基于变压吸附制氧原理产生纯氧,并采用微透镜阵列多光谱LED发光器件与二次透镜阵列相结合构成光动力治疗辐照器,研制一种纯氧及LED阵列光动力复合治疗设备。其辐照器输出纯氧浓度大于90%,照射光包括波长625 nm红光、465 nm蓝光和520 nm绿光,应用光排序辐照技术实现纯氧及多光谱光动力复合治疗。通过辐照器上纯氧和照射光同步输出等多种外源性给氧保持光动力治疗区域的富氧状态,解决由于乏氧影响光动力疗效的问题。辐照器光学系统解决现有技术采用LED阵列排布替代激光器作为光动力治疗光源时存在的光能利用率低、光功率密度分布不均匀、不同波长光束在目标靶面光功率密度分布曲面差异大等缺陷。

A novel treatment device for photodynamic therapy combining with pure oxygen and LED array is developed.The device can produce pure oxygen based on the principle of pressure swing adsorption,and there is a photodynamic therapy irradiator established by micro-lens array multi-wavelength LED and secondary lens array.The concentration of pure oxygen output by irradiator is higher than 90%.The light sources include 625 nm red light,465 nm blue light and 520 nm green light.The pure oxygen combined with multi-spectral photodynamic therapy is realized by light sorting irradiation technology.The problem that the therapeutic effect of photodynamic therapy is affected by the lack of oxygen is solved by a variety of exogenous oxygen such as the synchronous output of pure oxygen and light by the irradiator to maintain the photodynamic therapy area in oxygen-enriched environment.Moreover,the optical system of the irradiator takes LED array arrangement instead of laser as the light source of photodynamic therapy,thereby overcoming the defects of low utilization of light energy,uneven distribution of optical power density and large difference in the optical power density distribution surface of lights of different wavelengths on the target surface.