胆道闭锁患儿获得长期生存需要关注的问题

Several outstanding issues in long-term survival of children with biliary atresia

中国大陆胆道闭锁患儿的诊断和治疗水平已得到明显提高,而自体肝长期生存率及生存质量还需要进一步提高。对葛西手术后并发症及肝纤维化的长期规范随访,多学科合作的综合诊治,生长发育的长期监测,合理的营养及预防接种指导,以及肝移植的最佳时机选择,是帮助胆道闭锁患儿获得高质量长期生存的重要因素。

The diagnosis and treatment of children with biliary atresia(BA)in China mainland have significantly improved.However,long-term native liver survival rate and quality of life should be further optimized.Long-term standard follow-ups of Kasai postoperative complications and liver fibrosis,comprehensive treatments with multidisciplinary cooperations,long-term monitoring of growth and development,reasonable nutrition and vaccination guidance and appropriate timing for liver transplantation are the critical factors to help BA children to obtain long-term high-quality survival.