三仁汤合泻黄散加减联合西药治疗脾胃湿热型小儿厌食症临床研究

Clinical Study on Modified Sanren Tang and Xiehuang Powder Combined with Western Medicine for Infantile Anorexia of Spleen-stomach Dampness-heat Type

目的:观察三仁汤合泻黄散加减联合西药治疗脾胃湿热型小儿厌食症的临床疗效。方法:选取104例脾胃湿热型厌食症患儿,按照随机数字表法分为对照组和观察组各52例。对照组给予葡萄糖酸锌口服液、复合维生素B治疗,观察组在对照组基础上加用三仁汤合泻黄散加减治疗,2组均持续治疗3周。比较2组临床疗效、中医证候评分、食欲恢复正常时间、食量恢复正常时间及血红蛋白、微量元素水平,记录不良反应发生情况。结果:观察组总有效率为96.15%,高于对照组的82.69%(P<0.05)。治疗后,2组食少纳呆、神疲乏力及小便溲黄评分均较治疗前降低(P<0.05),观察组上述3项中医证候评分均低于对照组(P<0.05)。观察组食欲恢复正常时间、食量恢复正常时间均短于对照组(P<0.05)。治疗后,2组血红蛋白、血锌、血钙水平均较治疗前升高(P<0.05),观察组血红蛋白、血锌、血钙水平均高于对照组(P<0.05)。2组用药后均无明显不良反应发生。结论:三仁汤合泻黄散加减联合西药治疗脾胃湿热型小儿厌食症,可有效缓解患儿的临床症状,尽早恢复其食欲、食量,改善患儿的营养状况,具有良好的疗效和安全性。

Objective:To observe the clinical effect of modified Sanren tang and Xiehuang powder combined with western medicine for infantile anorexia of spleen-stomach damp-heat type.Methods:A total of 104 cases of children with anorexia of spleen-stomach dampness-heat type were selected and divided into the control group and the observation group according to the random number table method,52 cases in each group.The control group was treated with zinc gluconate oral solution and compound vitamin B,and the observation group was additionally treated with modified Sanren tang and Xiehuang powder based on the treatment of the control group.Both groups were treated for three weeks.The clinical effect,Chinese medicine syndrome scores,recovery time of appetite and food intake as well as the levels of hemoglobin and trace elements in the two groups were compared;the incidence of adverse reactions was recorded.Results:The total effective rate was 96.15%in the observation group,higher than that of 82.69%in the control group(P<0.05).After treatment,the scores of poor appetite and torpid intake,fetid mouth odor and sticky tongue and dry stool in the two groups were all decreased when compared with those before treatment(P<0.05),and the scores of the above three Chinese medicine syndromes in the observation group were all lower than those in the control group(P<0.05).The recovery time of appetite and food intake in the observation group was shorter than that in the control group(P<0.05).After treatment,the levels of hemoglobin,blood zinc and blood calcium in the two groups were increased when compared with those before treatment(P<0.05),and the above levels in the observation group were all higher than those in the control group(P<0.05).After administration,there was no obvious adverse reaction being found in the two groups.Conclusion:The therapy of modified Sanren tang and Xiehuang powder combined with western medicine for infantile anorexia of spleen-stomach dampnessheat type can effectively relieve the clinical symptoms of children,recover their appetite and food intake as soon as possible,and improve their nutritional status with good curative effect and safety.