血清CRP、IL-6、PCT在支气管扩张症合并肺部感染中的表达水平及意义

Expression levels of serum CRP,IL-6 and PCT of bronchiectasis patients complicated with pulmonary infection and their significance

目的探讨支气管扩张症合并肺部感染患者血清C-反应蛋白(C-reactive protein,CRP)、白细胞介素-6(Interleukin 6,IL-6)和降钙素原(Procalcitonin,PCT)的表达水平及意义。方法选取2017年1月-2019年5月海南医学院第一附属医院呼吸内科收治的支气管扩张症合并肺部感染患者90例为感染组,同期收治的未合并感染患者50例为未感染组。采集感染患者临床样本,进行病原菌分析。采集两组患者外周静脉血,检测血清CRP、IL-6、PCT的表达水平。结果90例支气管扩张症合并感染患者共送检标本90份,检出95株病原菌,其中以革兰阴性菌为主,占72.63%。感染组患者血清CRP、IL-6、PCT浓度分别为[(65.29±14.04)mg/L、(9.26±1.24)pg/ml、(5.65±1.42)ng/ml]显著高于未感染组[(13.56±1.01)mg/L、(7.36±1.67)pg/ml、(1.01±0.10)ng/ml],差异有统计学意义(P<0.05)。在感染组中,支气管扩张症病情越重,患者血清CRP、IL-6、PCT表达水平越高(P<0.05);感染越严重,患者血清CRP、IL-6、PCT表达水平越高(P<0.05)。革兰阴性菌感染患者血清CRP、IL-6、PCT水平均高于革兰阳性菌和真菌感染患者(P<0.05),而革兰阳性菌和真菌感染患者比较差异无统计学意义。结论支气管扩张症合并感染患者血清CRP、IL-6、PCT表达水平显著升高,有助于判断病情严重程度,并指导临床用药。

OBJECTIVE To explore the expression levels of serum C-reactive protein(CRP),interleukin-6(IL-6)and procalcitonin(PCT)of the bronchiectasis patients complicated with pulmonary infection and analyze their significance.METHODS Totally 90 bronchiectasis patients complicated with infection who were treated in the First Affiliated Hospital of Hainan Medical College from Jan 2017 to May 2019 were chosen as the infection group,meanwhile,50 patients without infection were set as the non-infection group.The clinical specimens were collected from the patients with infection,the pathogens were identified,and the peripheral blood specimens were collected from the two groups of patients so as to determine the levels of serum CRP,IL-6 and PCT.RESULTS A total of 95 strains of pathogens were isolated from 90 submitted specimens of the 90 bronchiectasis patients complicated with infection,72.63%of which were gram-negative bacteria.The levels of serum CRP,IL-6 and PCT of the infection group were respectively(65.29±14.04)mg/L,(9.26±1.24)pg/ml and(5.65±1.42)ng/ml,significantly higher than(13.56±1.01)mg/L,(7.36±1.67)pg/ml and(1.01±0.10)ng/ml of the non-infection group(P<0.05).In the infection group,the severer the bronchiectasis,the higher the levels of serum CRP,IL-6 and PCT were(P<0.05).The severer the infection,the higher the levels of serum CRP,IL-6 and PCT were(P<0.05).The levels of serum CRP,IL-6 and PCT of the patients with gram-negative bacteria infections were significantly higher than those of the patients with gram-positive bacteria infections and the patients with fungal infections(P<0.05),however,there were no significant differences between the patients with gram-positive bacteria infections and the patients with fungal infections.CONCLUSION The expression levels of serum CRP,IL-6 and PCT of the bronchiectasis patients complicated with infection are significantly elevated,which may facilitate the judgment of severity of disease and provide guidance for clinical use of antibiotics.