妊娠晚期B族溶血性链球菌宫内感染血清IL-6和TNF-α表达水平与妊娠结局

Correlation between levels of serum IL-6 and TNF-alpha and pregnancy outcomes of pregnant women with intrauterine infection of group B hemolytic Streptococcus in third trimester of pregnancy

目的探讨B族溶血性链球菌(group B Streptococcus,GBS)宫内感染妊娠晚期孕妇血清白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)表达水平与妊娠结局的关系。方法选取2014年12月-2017年12月贵州中医药大学第一附属医院收治的90例妊娠晚期GBS感染孕妇作为感染组,另选取同期在贵州中医药大学第一附属医院进行产检的50例健康孕妇作为对照组。比较两组孕妇血清IL-6、TNF-α表达水平,比较GBS感染孕妇不同妊娠结局血清IL-6、TNF-α表达水平。结果感染组血清IL-6、TNF-α水平分别为(78.25±12.26)ng/L和(62.24±9.24)ng/L,明显高于对照组的(42.01±10.01)ng/L和(30.05±7.36)ng/L,比较差异有统计学意义(P<0.05)。感染组剖宫产、早产、胎膜早破、产褥感染、胎儿窘迫和新生儿病理性黄疸的发生率分别为41.11%、20.00%、21.11%、18.89%、18.89%、16.67%,明显高于对照组,差异有统计学意义(P<0.05)。不良妊娠结局GBS感染产妇血清IL-6、TNF-α分别为(82.36±17.05)ng/L和(67.50±12.01)ng/L,明显高于正常妊娠结局GBS感染产妇(P<0.05)。结论妊娠晚期GBS感染孕妇血清IL-6和TNF-α表达水平明显高于健康孕妇,IL-6和TNF-α表达水平越高,GBS感染孕妇妊娠结局越差。

OBJECTIVE To explore the correlation between the levels of serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)and the pregnancy outcomes of the pregnant women with intrauterine infection of group B hemolytic Streptococcus in third trimester of pregnancy.METHODS Totally 90 pregnant women with GBS infection in third trimester of pregnancy who were treated in the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from Dec 2014 to Dec 2017 were chosen as the infection group,meanwhile,50 healthy pregnant women who received prenatal care in the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine were set as the control group.The levels of serum IL-6 and TNF-αwere compared between the two groups of pregnant women,and the levels of serum IL-6 and TNF-αwere compared among the GBS infection pregnant women with different pregnancy outcomes.RESULTS The levels of serum IL-6 and TNF-αof the infection group were respectively(78.25±12.26)ng/L and(62.24±9.24)ng/L,significantly higher than(42.01±10.01)ng/L and(30.05±7.36)ng/L of the control group,and there were significant differences(P<0.05).The incidence rates of cesarean section,premature delivery,premature rupture of membranes,puerperal infection,fetal distress and neonatal pathological jaundice of the infection group were respectively 41.11%,20.00%,21.11%,18.89%,18.89%and 16.67%,significantly higher than those of the control group,and there were significant differences(P<0.05).The levels of serum IL-6 and TNF-αof the GBS infection pregnant women with adverse pregnancy outcomes were respectively(82.36±17.05)ng/L and(67.50±12.01)ng/L,significantly higher than those of the GBS infection pregnant women with normal pregnancy outcomes(P<0.05).CONCLUSION The levels of serum IL-6 and TNF-αof the GBS infection pregnant women in third trimester of pregnancy are significantly higher than those of the healthy pregnant women.The higher the levels of IL-6 and TNF-α,the worse the pregnancy outcomes of the pregnant women with GBS infection are.