维持性血液透析患者机体营养状况及IL-10基因多态性与肺部感染的相关性

Correlation between nutrition status,IL-10 gene polymorphism and pulmonary infection in maintenance hemodialysis patients

目的分析维持性血液透析患者机体营养状况及IL-10基因多态性与肺部感染的相关性,为维持性血液透析患者肺部感染的早期干预与治疗提供依据。方法选择2018年3月-2019年3月贵州中医药大学第一附属医院收治的终末期肾病维持性血液透析患者146例为研究对象,根据患者是否发生肺部感染,分为肺部感染组患者54例、未感染组患者92例。分析两组患者营养状况评分及血清白蛋白水平,并检测患者白细胞介素-10(IL-10)的基因多态性。结果两组患者年龄、病程以及平均透析时间比较差异有统计学意义(P<0.05)。肺部感染组患者营养状况评分(18.94±3.42)分高于未感染组,血清白蛋白水平(23.47±4.29)g/L低于未感染组(均P<0.05)。两组患者IL-10 rs1554286位点基因型比较差异有统计学意义(P<0.05),肺部感染组患者IL-10 rs1554286位点G等位基因频率高于未感染组(P<0.05)。肺部感染组患者IL-10 rs1518111位点基因型与未感染组患者比较差异有统计学意义(P<0.05),肺部感染患者IL-10 rs1518111位点C等位基因频率高于未感染组(P<0.05)。结论维持性血液透析肺部感染患者营养状况差、血清白蛋白水平低,此外肺部感染的发生与患者IL-10基因多态性有关。

OBJECTIVE To analyze the correlation between the nutrition status,IL-10 gene polymorphism and the pulmonary infection in the maintenance hemodialysis patients so as to provide guidance for early intervention to the pulmonary infection and treatment of the maintenance hemodialysis patients.METHODS A total of 146 patients with end-stage renal disease who received maintenance hemodialysis in the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from Mar 2018 to Mar 2019 were enrolled in the study and divided into the pulmonary infection group with 54 cases and the non-infection group with 92 cases according to the status of pulmonary infection.The score of nutrition status and serum albumin level of the two groups of patients were observed,and the gene polymorphism of interleukin-10(IL-10)of the patients was detected.RESULTS There were significant differences in the age,course of disease and average time of dialysis between the two groups of patients(P<0.05).The score of nutrition status of the pulmonary infection group was(18.94±3.42)points,significantly higher than that of the non-infection group;the serum albumin level of the pulmonary infection group was(23.47±4.29)g/L,lower than that of the non-infection group(all P<0.05).There was significant difference in the genotype of IL-10 rs1554286 locus between the two groups of patients(P<0.05),the G allele frequency of IL-10 rs1554286 locus of the pulmonary infection group was significantly higher than that of the non-infection group(P<0.05).There was significant difference in the genotype of IL-10 rs1518111 locus between the pulmonary infection group and the non-infection group(P<0.05),and the C allele frequency of IL-10 rs1518111 locus of the pulmonary infection group was significantly higher than that of the non-infection group(P<0.05).CONCLUSION The maintenance hemodialysis patients with pulmonary infection present with poor nutrition status and low level of serum albumin,and the incidence of pulmonary infection is associated with the IL-10 gene polymorphism.