肠道菌群对外科术后肠道功能障碍影响机制研究进展

Advance in research on influence of intestinal flora on postoperative ileus

外科术后肠道功能障碍(Postoperative ileus,POI)是医源性腹部甚至非腹部手术的并发症,近年来随着快速康复外科的发展,POI常因延长患者住院时间和增加住院费用而被认为是影响患者术后康复的核心环节。定植于人体肠道中的菌群在调节肠道功能与维持肠道稳态等生命活动中发挥着重要的作用。近年来大量的基础研究提示肠道菌群对POI的启动免疫、脑-肠互动、抗击炎症、调节肠道内分泌、生物屏障等方面起着重要作用。本文就肠道菌群对POI发生及发展的相关调节机制进行综述。

Postoperative ileus(POI)is an iatrogenic abdominal or even non-abdominal surgery complication.In recent years,with the development of rapid recovery surgery,POI was regarded as the core link to influence the postoperative recovery due to the prolonged hospitalization duration and the increase of hospitalization cost.The flora colonized in the intestinal tract play an important role in vital activities such as regulating intestinal function and maintaining homeostasis.In recent years,a large number of fundamental researches showed that the intestinal flora play important role in triggering immune responses,regulating brain-gut communication,and participating in anti-inflammatory functions,regulating secretion and barrier function.The related regulatory mechanisms of the intestinal flora on occurrence and progression of POI were reviewed in the article.