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hERG钾通道失活机制的研究进展

Research Advances in Inactivation Mechanism of hERG Potassium Ion Channel
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摘要 h ERG(Human ether-a-go-go-related gene)钾通道是KCNH2基因编码的一种内向整流钾通道。h ERG钾通道产生的IKr是心肌细胞复极化过程中重要的离子流,有助于心室动作电位的复极化。h ERG钾通道的门控动力学特点是缓慢的激活和快速的失活,失活过程加快是导致长QT综合征和致死性心律失常的一种常见机制。文章综述了h ERG钾通道失活机制方面的研究进展。 The h ERG(Human ether-a-go-go-related gene)potassium ion channel is an inward rectifier potassium ion channel encoded by the KCNH2 gene.The IKr current produced by the h ERG potassium channel is an important ion current in the process of repolarization of cardiomyocytes,which contributes to the repolarization of ventricular action potential.Its gated kinetics is slow activation and fast inactivation.Accelerated inactivation is a common mechanism leading to long QT syndrome and fatal arrhythmia.This paper reviews the research progress in the mechanism of h ERG potassium channel inactivation.
作者 郄艮朝 陈渊 赵伟 QIE Gen-chao;CHEN Yuan;ZHAO Wei(Institute of Traditional Chinese Medicine,School of Forestry and Biotechnology,Zhejiang A&F University,Hangzhou 311300,China)
机构地区 浙江农林大学林业与生物技术中药学科
出处 《药物生物技术》 CAS 2020年第2期154-159,共6页 Pharmaceutical Biotechnology
基金 浙江农林大学科研发展基金资助项目(No.2013FR032) 浙江省基础公益研究计划项目(No.LGF18H280002)。
关键词 HERG钾通道 失活 长QT综合征 hERG钾通道结构 心律失常 心肌细胞 HERG potassium channel Inactivation Long QT syndrome HERG potassium channel structure Arrhythmia Cardiomyocytes
分类号 Q71 [生物学—分子生物学]
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