Akt对心脏和骨骼肌的调控作用

Regulatory Role of Akt in Heart and Skeletal Muscle

丝氨酸/苏氨酸激酶Akt也称蛋白激酶B(PKB),参与调节细胞的生长、代谢、增殖和分化等多种生理活动,磷酸肌醇3激酶(PI3K)是Akt上游的信号分子,PI3K-Akt通路与疾病的发生密切相关。文章综述了Akt对心脏的影响以及在骨骼肌发育和代谢过程中发挥的调控作用。

The serine/threonine Akt kinase,also known as protein kinase B(PKB),was involved in the regulation of cell growth,metabolism,proliferation and differentiation.The phosphoinositide 3-kinase(PI3 K)was a signal molecule upstream of Akt.The PI3 K-Akt pathway was closely related to the occurrence of disease.The effects of Akt on the heart and its regulatory role in skeletal muscle development and metabolism were reviewed.