秀丽隐杆线虫模型在食品安全研究中的应用

Application of Caenorhabditis elegans Model in Food Safety Research

食品安全涉及民生,一直以来都是研究的热点。在食品安全研究中,需要通过动物实验评价其毒理等性质,然而因伦理、成本和实验周期等问题而受到一定限制。因秀丽隐杆线虫结构简单、试验周期短以及信号通路高度保守等特性而为食品安全快速评价提供了一个新选择。本文详细介绍了秀丽隐杆线虫的同源性、免疫防御机制的保守性以及在食品安全方面的应用研究,包括各种外界危害因子的毒性机理和线虫自身的免疫防御的调控机制等,并分析了秀丽隐杆线虫的应用前景,为秀丽隐杆线虫在食品安全评价中的应用提供一定的参考。

Food safety issues have always been a research hotspot because they involve people’s livelihood.In food safety research,animal toxicity needs to be evaluated through animal experiments.However,due to ethical issues,costs,and experimental cycles,certain limitations have been encountered.Caenorhabditis elegans has a simple structure,a short test cycle,and a highly conservative signaling pathway.Such characteristics provide a new choice for rapid evaluation of food safety.This article describes in detail the homology of C.elegans and the conservation of the immune defense mechanism,and its application research in food safety,including the toxicity mechanism of various external hazard factors,and the regulatory mechanism of the immune defense of C.elegans.And analyzed the application of Caenorhabditis elegans.It provides a certain reference for the application of Caenorhabditis elegans in food safety evaluation.