摘要
Various behaviors of cancer cells are strongly influenced by their interaction with extracellular matrices(ECM).We investigate how this interaction may be influenced if the cancer cells’ability of secreting matrix metalloproteinases(MMPs)to degrade ECM is inhibited by adding the MMP inhibitor.We useMDA-MB-231-GFP cells as model cells and use matrigel to mimic ECM.It is found that the added MMP inhibitor significantly reduces the migration speed of cancer cells covered by matrigel but has little influence on the migration persistence and shape factor of the cells and that with the MMP inhibitor added the presence of matrigel on the top has no influence on the migration speed of the cells but increases the cells’shape factor and migration persistence.
作者
叶腾
叶方富
邱峰
Teng Ye;Fangfu Ye;Feng Qiu(First Clinical Medical College,Nanchang University,Nanchang 330006,China;Beijing National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of Sciences,Beijing 100190,China;Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China;Department of Oncology,First Affiliated Hospital of Nanchang University,Nanchang 330006,China)
基金
National Natural Science Foundation of China(Grant No.11774394)
the Key Research Program of Frontier Sciences of Chinese Academy of Sciences(Grant No.QYZDB-SSW-SYS003)
the K.C.Wong Education Foundation.
