尿酸相关代谢和免疫调控因子在银屑病发病中的作用和意义

The role and significance of uric acid-related metabolic and immune regulatory factors in the pathogenesis of psoriasis

目的探讨尿酸相关代谢和免疫调控因子在银屑病发病机制中的作用和意义。方法利用日本HITACHI-7180全自动生化分析仪和美国Luminex 200液相芯片检测系统,检测70例银屑病患者血清中尿酸(uric acid,UA)、肿瘤坏死因子α(tumor necrosis factor,TNF-α)、脂联素(Adiponectin)水平,并进行统计分析。结果与正常人比较,银屑病患者血清中UA水平升高,差异有统计学意义(P<0.05);TNF-α水平明显升高,而Adiponectin水平则明显下降,差异均有高度统计学意义(P<0.01)。经Spearman相关分析,银屑病患者血清中UA与TNF-α呈正相关(P<0.05),与Adiponectin呈负相关(P<0.05)。而银屑病皮损面积与严重度积分PASI与外周血清中UA、TNFα、Adiponectin均无相关性(P>0.05)。结论银屑病患者血清UA升高可能通过促炎因子TNF-α在银屑病免疫炎症的发生和持续放大中起到关键作用,并通过抗炎因子Adiponectin的缺失使银屑病免疫炎症和代谢紊乱进一步加重。

Objective To investigate the role and significance of uric acid-related metabolic and immune regulatory factors in pathogenesis of psoriasis.Methods The serum levels of uric acid,tumor necrosis factor-αand adiponectin in 70 patients with psoriasis were detected and analyzed by HITACHI-7180 automatic biochemical analyzer and Luminex 200 liquid phase chip detection system.Results Compared with normal subjects,The serum UA level in patients with psoriasis increased,with statistically significant difference(P<0.05).The level of TNF-αincreased significantly,while the level of Adiponectin decreased significantly,both of which were highly statistically significant(P<0.01).Spearman correlation analysis showed that serum UA in patients with psoriasis was positively correlated with TNF-α(P<0.05)and negatively correlated with Adiponectin(P<0.05).However,the PASI of patients with psoriasis were not correlated with UA,TNF and Adiponectin in their serums(P>0.05).Conclusion Serum UA elevation in patients with psoriasis may play a key role in the occurrence and amplification of immune inflammation in psoriasis through the pro-inflammatory factor TNF-α,and further aggravate immune inflammation and metabolic disorders in psoriasis through the absence of anti-inflammatory factor Adiponectin.