摘要
目的酸枣仁珍珠粉胶囊的大鼠30天喂养试验安全性考察。方法实验动物随机分四组,受试物组剂量分别为0.50g/(kg·bw)、1.00g/(kg·bw)、2.00g/(kg·bw),对照组给予蒸馏水,每日灌胃,连续30天。每周称一次体重,计算食物摄入量和食物利用率。30天后,检测大鼠血常规、血生化、脏器重量及脏器/体重比值,并进行大体解剖及组织学检查。结果实验期间,动物生长发育良好,各剂量组体重、增重、食物利用率、血常规指标、血生化指标、脏器重量及脏器/体重比值与对照组比较,无显著性差异。大体解剖和组织病理检查未见与样品有关的异常改变。结论样品30天喂养对大鼠未见明显毒副作用,在本试验的剂量范围内,酸枣仁珍珠粉胶囊是安全的。
Objective The safety of semen zizyphi spinosus pearl powder capsule in 30 day feeding test in rats.Methods The experimental animals were randomly divided into four groups.The doses of the test substance group were 0.50g/(kg·bw),1.00g/(kg·bw)and 2.00g/(kg·bw)respectively.The control group was given distilled water.Daily gavage for 30 days.Weigh once a week,calculate food intake and food utilization.After 30 days,the blood routine,blood biochemistry,organ weight and organ/body weight ratio were measured,and the gross anatomy and histology were examined.Results During the experiment,the growth and development of animals were good.There was no significant difference in body weight,weight gain,food utilization rate,blood routine index,blood biochemical index,organ weight and organ/body weight ratio between each dose group and the control group.No abnormal changes related to the samples were found in gross anatomy and histopathology.Conclusion The 30 day feeding of the sample has no obvious toxic and side effects on rats.In the dose range of this experiment,semen zizyphi spinosae pearl powder capsule is safe.
作者
郭婉
李卓
杜显龙
孙雨薇
GUO Wan;LI Zhuo;DU Xianlong;SUN Yuwei(Nanjing Shengnuo Bio-technology Industry co., LTD. Jiangsu 212000, China)
出处
《中国老年保健医学》
2020年第3期33-36,共4页
Chinese Journal of Geriatric Care
关键词
酸枣仁
珍珠粉
毒理学
大鼠喂养试验
semen zizyphi spinosae
pearl powder
toxicology
rat feeding test