摘要
血管紧张素转换酶2(ACE2)及其代谢产物作为心血管系统重要的神经体液调节因子,可通过ACE2-Ang-(1-7)-Mas轴对整个心血管系统产生影响.新型冠状病毒(SARS-CoV2)主要通过与细胞表面的ACE2分子受体结合进入人体细胞,导致靶器官受损的同时引发一系列临床症状,而心脏作为高表达ACE2分子的器官,由此带来的受累程度及损伤机制尚未明确.本文就ACE2及ACE2-Ang-(1-7)-Mas调节轴的生理学特性及其在心血管系统疾病中的作用和影响作一综述,为新型冠状病毒感染后心脏受损机制的探讨提供思路.
As an important regulator in the cardiovascular system,ACE2 and its metabolites can affect the metabolism of the entire cardiovascular system through the ACE2-Ang-(1-7)-Mas axis.The novel coronavirus(SARS-CoV2)enters human cells mainly by binding to ACE2 molecular receptor expressing on the cell surface,causing damage to the target organ and a series of clinical symptoms.However,the heart,as an organ with high expression of ACE2 molecule,has not yet been clear in the involved degree and mechanism of the damage.In this paper,the physiological characteristics of ACE2 and ACE2-Ang-(1-7)-Mas regulatory axis,its role and influence in cardiovascular system diseases are reviewed to provide ideas for the investigation of the mechanism of cardiac damage after the SARS-CoV2 infection.
作者
韩宗茂
高洁
高传玉
HAN Zong-mao;GAO Jie;GAO Chuan-yu(Department of Cardiology,People's Hospital of Zhengzhou University,People's Hospital of Henan Province,Fu Wcii Central China Cardiovascular Hospital,Zhengzhou 450003,China;Department of Anesthesia,People's Hospital of Zhengzhou University,People's Hospital of Henan Province,Fu Wai Central China Cardiovascular Hospital,Zhengzhou 450003,China)
出处
《中国心血管病研究》
CAS
2020年第6期542-546,共5页
Chinese Journal of Cardiovascular Research
关键词
血管紧张素转换酶2
新型冠状病毒
肾素-血管紧张素系统
高血压
心力衰竭
冠状动脉粥样硬化心脏病
心房颤动
Angiotensin converting enzyme 2
Severe acute respiratory syndrome coronavirus-2
Renin angiotensin system
Hypertension
Heart failure
Coronary atherosclerotic heart disease
Atrial fibrillation