急性白血病患者常用化疗药物的遗传药理学研究进展

Pharmacogenetics progress of commonly-used chemotherapeutic drugs for acute leukemia

白血病是常见的、危害人类健康的疾病,其主要治疗手段为化疗。在长期的临床应用过程中,临床医生发现这些药物虽然疗效显著但是存在明显的个体差异。如何更多了解可能引起化疗药物耐药及不良反应的因素,从而提高化疗药物的疗效,降低耐药及减少药物的不良反应,是目前临床工作者关心的问题。文章综述了影响临床常用的几种化疗药物的遗传因素,旨在为这些化疗药物临床个体化给药提供一定的参考依据。

Leukemia is a common and harmful disease for humans.Chemotherapy is the main treatment method.During the decades of experience,the clinicians have found that these drugs work well,but obvious individual differences occur in different patients.Some concerns of the clinicians exist such as how to learn more about the factors that may induce drug resistance and adverse reactions,and how to improve the efficacy of chemotherapy drugs,reduce drug resistance and side effects.This paper reviews the effect of genetic factors of commonly-used chemotherapeutic drugs for acute leukemia,aiming to provide a theoretical foundation for personalized administration of these chemotherapeutic drugs.