妊娠合并病毒性肝炎患者血清甲状腺素水平与母婴结局的关系

Relationship between serum thyroxine levels and maternal and fetal outcomes in patients with pregnancy complicated with viral hepatitis

目的探讨研究妊娠合并病毒性肝炎患者血清甲状腺素水平与母婴结局的关系。方法选取2016年2月-2018年2月在该院分娩的58例妊娠合并病毒性肝炎患者为研究组,另选取同期在该院分娩的60例健康孕妇作为对照组,使用全自动电化学发光分析仪检测患者血清中甲状腺素水平,记录孕妇不良反应发生情况:流产、心力衰竭、糖代谢异常、贫血、先兆子痫、妊娠期高血压疾病,记录胎儿、新生儿不良反应:新生儿并发症、低体质量儿、畸胎、胎盘早剥、胎儿宫内窘迫、早产、胎膜早破。结果研究组孕妇妊娠15、25、35周三碘甲状腺原氨酸(T3)和四碘甲状腺原氨酸(T4)水平均高于对照组(P<0.05);两组孕妇先兆子痫发生率比较,差异无统计学意义(P>0.05);研究组孕妇流产、心力衰竭、妊娠期糖代谢异常、贫血、妊娠期高血压疾病发生率均高于对照组(均P<0.05);两组胎儿胎膜早破发生率比较,差异无统计学意义(P>0.05);研究组胎儿宫内窘迫、胎盘早剥、早产、畸胎、低体质量儿、新生儿并发症发生率均高于对照组(P<0.05)。结论妊娠合并病毒性肝炎患者血清甲状腺素高水平表达,导致孕妇、胎儿、新生儿不良结局发生率明显升高,通过检测孕妇血清甲状腺素水平可为判断母婴结局提供参考。

Objective To investigate the relationship between serum thyroxine levels and maternal and fetal outcomes in patients with viral hepatitis.Methods A total of 58 pregnant patients with viral hepatitis who were delivered in our hospital from February 2016 to February 2018 were selected as the study group.60 normal pregnant women who were delivered in our hospital were selected as the control group,and a fully automated electrochemiluminescence analyzer was used.Detection of thyroxine levels in patients'serum,recording adverse reactions in pregnant women:abortion,heart failure,abnormal glucose metabolism,anemia,pre-eclampsia,pregnancy-induced hypertension,recording fetal,neonatal adverse reactions:neonatal complications,low birth weight infants Teratogenicity,placental abruption,intrauterine distress,premature delivery,premature rupture of membranes.Results The levels of iodine thyronine(T3)and tetraiodothyronine(T4)in pregnant women in the study group were higher than those in the control group at 15 weeks of gestation,25 weeks of gestation and 35 weeks of gestation,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of pre-eclampsia between the two groups(P>0.05).The incidence of abortion,heart failure,abnormal glucose metabolism during pregnancy,anemia,and pregnancy-induced hypertension were higher in the study group than in the control group.Significance(P<0.05);there was no significant difference in the incidence of premature rupture of fetal membranes between the two groups(P>0.05).The study group had intrauterine distress,placental abruption,premature delivery,teratogenesis,low birth weight,and neonatal complications.The incidence of symptoms was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The high level of serum thyroxine in pregnant patients with viral hepatitis leads to a significant increase in the incidence of adverse outcomes in pregnant women,fetuses,and neonates.The detection of serum thyroxine levels in pregnant women can provide a reference for judging maternal and infant outcomes.